Effects of Alprostadil Combined with Epalrestat on Ulcer Area,Vascular Diameter and Oxidative Stress in Patients with Diabetic Foot
Objective:To investigate the effect of alprostadil combined with epalrestat in the treatment of patients with diabetic foot(DF),and its influence on ulcer area,vascular diameter and oxidative stress.Methods:From February 2021 to February 2023,92 patients with DF admitted to a hospital were divided into the control group and the experimental group by the random number table method,with 46 patients each.Both groups were given conventional treatment such as insulin,the control group was given alprostadil injection on the basis of conventional treatment,and the experimental group was given epalrestat tablets on the basis of control group.Both groups were treated continuously for 14 days.The clinical efficacy,healing status of foot ulcer(ulcer area,wound oxygen partial pressure,wound pH),hemodynamic indexes of dorsal foot artery[blood vessel diameter,blood flow velocity,pulsation index(PI),resistance index(RI)],oxidative stress indexes[superoxide dismutase(SOD),malondialdehyde(MDA)]and occurrence of adverse reactions were compared between the two groups.Results:After treatment,the overall effective rate in the experimental group(95.65%)was higher than that in the control group(80.43%,P<0.05).The ulcer area and wound pH were reduced in both groups(P<0.05),with the experimental group showing a lower reduction than the control group(P<0.05).The wound oxygen partial pressure in both groups was elevated(P<0.05),with the experimental group showing a higher elevation than the control group(P<0.05).The blood vessel diameter,blood flow velocity and PI level were increased in both groups(P<0.05),with the experimental group showed a higher increase than the control group(P<0.05).The RI level was decreased in both groups(P<0.05),with the experimental group showing a lower decrease than the control group(P<0.05).The serum SOD level was increased in both groups(P<0.05),with the experimental group showing a higher increase than the control group(P<0.05).The serum MDA level was decreased in both groups(P<0.05),with the experimental group showing a lower increase than the control group(P<0.05).The overall incidence of adverse reactions such as dizziness,headache,nausea,vomiting and other adverse reactions during the treatment period of the two groups of patients were not statistically different(P>0.05).Conclusion:On the basis of conventional treatment,alprostadil and epalrestat in the treatment of DF patients have significant clinical effect,which can effectively improve the hemodynamics level of dorsal foot arteries,reduce the area of foot ulcers,and reduce oxidative stress damage.
万方数据
维普
