The Efficacy of Jinlida Granule in Combination with Tripterygium Glycosides Tablets in Patients with Diabetic Nephropathy and Its Effect on Immune Function
Objective:To investigate the efficacy of Jinlida granule in combination with tripterygium glycosides tablet in patients with diabetic nephropathy(DN)and its effect on immune function.Methods:A total of 102 patients with DN admitted to the hospital from October 2020 to January 2022 were randomly assigned to either the control group(n=47)or the observation group(n=55).The control group took tripterygium glycoside tablets orally,while the observation group was given Jinlida granules orally in addition to the treatment of the control group.Besides the renal function indicators such as β2-microglobulin(β2-MG),urinary albumin excretion rate(UAER),blood urea nitrogen(BUN),serum creatinine(Scr)and 24h urinary protein quantification,TCM symptom score,inflammatory factors such as serum C-reactive protein(CRP),tumor necrosis factor(TNF-α),interleukin-6(IL-6),peripheral blood T lymphocyte subsets such as CD3+,CD4+,CD4+/CD8+,thromboxane B2(TXB2),endothelin-1(ET-1),nitric oxide(NO),and changes in thrombomodulin(TM)level before and after the treatment,the clinical efficacy and occurrence of adverse reactions before and after treatment were also compared between the two groups.Results:Following treatment,the quantitative levels of β2-MG,UAER,BUN,Scr and 24h urinary protein,the TCM symptom scores,as well as the serum levels of CRP,IL-6 and TNF-α in both groups significantly decreased(P<0.05),with a more significant decrease observed in the observation group compared to the control group(P<0.05).While,the levels of serum CD3+,CD4+ and CD4+/CD8+ improved in both groups,with CD3+and CD4+/CD8+ improved more significantly in the observation group compared to the control group(P<0.05);the levels of serum TXB2,ET-1,TM and NO improved in both groups,with a more significant improvement observed in the observation group(P<0.05).Following treatment,the overall response rate in the observation group(96.36%)is higher than in the control group(78.72%,P<0.05).But no significant statistical difference was observed in the overall incidence of adverse reactions occurred in both groups.Conclusion:Jinlida granules in combination with tripterygium glycosides tablets demonstrates good clinical efficacy in the treatment of diabetic nephropathy,which can alleviate microcirculation disorder and improve endothelial function,renal and immune function in patients with DN.
Jinlida granuletripterygium glycosides tabletsdiabetic nephropathyclinical efficacykidney function
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