首页|温润辛金方治疗微寒恋肺型咳嗽变异型哮喘的临床疗效研究

温润辛金方治疗微寒恋肺型咳嗽变异型哮喘的临床疗效研究

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目的:观察温润辛金方治疗微寒恋肺型咳嗽变异型哮喘(CVA)的临床疗效及安全性,为CVA的中医临床治疗提供依据和思路.方法:选取2017年6月~2019年12月期间于某院就诊的60例微寒恋肺型CVA患者,根据随机数字表法分为对照组和观察组,每组30例.对照组给予沙美特罗替卡松吸入粉雾剂,观察组给予温润辛金方,两组均治疗6周.观察两组患者的中医证候疗效以及不良反应,比较两组患者治疗前后呼出气一氧化氮(FeNO)及咳嗽症状积分的变化.结果:对照组和观察组分别脱落2例和4例.两组临床治疗总有效率比较无统计学差异(P>0.05).治疗后,两组咳嗽症状积分、FeNO均较治疗前下降(P<0.05),且观察组咳嗽症状积分低于对照组(P<0.05),但两组FeNO水平比较无统计学差异(P>0.05).观察组有2例患者在服药期间出现恶心等胃部不适,嘱其改为饭后服药后症状消失;对照组有2例患者出现轻微不良反应,但不影响后续治疗.结论:温润辛金方可有效改善微寒恋肺型CVA患者的临床症状和咳嗽症状积分,临床疗效较佳且安全性良好.
Clinical Study on the Therapeutic Effects of Wenrunxinjin Decoction in the Treatment of Cough Variant Asthma with Mild Cold Lingering Lung
Objective:To explore the clinical effect of Wenrunxinjin decoction on cough variant asthma(CVA)with mild cold lingering lung.Method:A total of 60 patients with mild cold and lung-loving CVA treated in a hospital from June 2017 to December 2019 were selected and divided into control group and observation group according to random number table method,with 30 cases in each group.The control group was treated with salmeterol xinafoate and fluticasone propionate powder for inhalation,the treatment group was treated with Wenrunxinjin decoction.Both groups were treated for 6 weeks.The study observed the therapeutic effects of traditional Chinese medicine syndromes and adverse reactions in the two groups,and compared the changes in fractional exhaled nitric oxide(FeNO)and cough symptom scores before and after treatment.Results:2 cases of detachment in the control group and 4 cases in the treatment group,respectively.The total effective rate was not statistically significant between the two groups(P>0.05).After treatment,the cough symptom score and FeNO were significantly reduced(P<0.05).The score of cough symptom in observation group was lower than that in control group(P<0.05);However,the difference in FeNO was not statistically significant(P>0.05).There were 2 patients in the observation group who had stomach discomfort such as nausea during medication,and the symptoms disappeared after they were instructed to take medicine after meals.In the control group,2 patients had mild adverse reactions,which did not affect subsequent treatment.Conclusion:The Wenrunxinjin decoction significantly improves clinical symptoms,cough symptom score in the treatment of CVA with mild cold lingering lung.It has better clinical efficacy and good safety.

Wenrunxinjin decoctionmild cold lingering lungcough variant asthmafractional exhaled nitric oxidecough symptom score

高金柱、苗青、樊茂蓉、丛晓东

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中国中医科学院西苑医院,北京100091

温润辛金方 微寒恋肺 咳嗽变异型哮喘 呼出气一氧化氮 咳嗽症状积分

中国中医科学院自主选题项目

ZZ0908039

2024

中国合理用药探索
中国执业药师协会

中国合理用药探索

影响因子:0.62
ISSN:2096-3327
年,卷(期):2024.21(2)
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