Objective:To analyze the occurrence of allergic-like reactions caused by ginkgolide injection,and provide reference for preventing adverse drug reactions(ADR)and ensure patient's medication safety.Methods:Collect the basic information on patients with allergic-like reactions caused by the use of ginkgolide injection reported to the National Adverse Drug Reaction Monitoring System in Fujian province from January 2004 to February 2023.The information includes gender,age,ADR occurrence time,involvement of systemic organ damage,clinical manifestations,etc.Statistical analysis was conducted.Results:A total of 348 ADR reports were included,including 130 males and 218 females,resulting in a male to female ratio of 0.6:1.The majority of patients were aged 60 years and above(272 cases,78.16%).ADR mainly occurred during the medication process(302 cases,86.78%).348 ADR reports involved a total of 622 clinical manifestations,including vascular and lymphatic vessel diseases(247 cases,39.71%),skin and subcutaneous tissue diseases(209 cases,33.60%),etc.New ADRs mainly manifested as rash,itching,etc.(333 cases,53.54%),while known ADRs mainly manifested as flushing,dizziness,nausea,etc.(289 cases,46.46%).After discontinuation of medication or symptomatic treatment,112 patients recovered(32.18%)or 236 patients improved(67.82%).Conclusion:Enhanced clinical monitoring of ginkgolide injection usage is recommended,with particular attention to ADRs during the medication process.Timely treatment should be administrated to ensure the patient safety during medication.
关键词
银杏内酯注射液/药品不良反应/过敏样反应/临床用药/监测
Key words
ginkgolide injection/adverse drug reactions/allergic-like reactions/clinical medication/monitor
维普
万方数据