Effect of Low-Dose Compound Betamethasone Combined with Platelet Rich Plasma in the Treatment of Knee Osteoarthritis
Objective:To investigate the application effect of low-dose compound betamethasonein combined with platelet rich plasma(PRP)the treatment of knee osteoarthritis(KOA).Methods:92 patients with KOA and admitted to the hospital between December 2021 and December 2022 were selected and assigned into the control group and the observation group using a simple random grouping method,with 46 cases in each group.All patients received the conventional drug for KOA(glucosamine sulfate capsules).The control group received PRP treatment,while the observation group additionally received low-dose compound betamethasone injection.The pain status[visual analogue scale(VAS),knee function recovery status[Lysholm knee score scale(LKSS)],knee joint activity[range of motion(ROM),Western Ontario and Mcmaster Universitiy osteoarthritis index(WOMAC)],daily living ability[Barthel index(BI)],walking ability,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results:After treatment,the VAS score decreased in both groups(P<0.05),with the observation group having a lower score than the control group(P<0.05).The LKSS score increased in both groups(P<0.05),with the observation group scoring higher than the control group(P<0.05).Both groups showed enhanced active and passive ranges of motion(P<0.05),with the observation group demonstrating higher ranges of motion(P<0.05).The WOMAC score decreased(P<0.05),with the observation group scoring lower than the control group(P<0.05).Both groups showed increased scores in BI and walking ability(P<0.05),with the observation group scoring higher than the control group(P<0.05).The total effective rate of treatment in the observation group(95.65%)was significantly higher than that in the control group(80.43%,P<0.05).There was no significant difference in the occurrence of adverse reactions between the two groups(χ2=0.212,P=0.646).Conclusion:The combination of PRP and low-dose compound betamethasone,in conjunction with conventional KOA drugs,demonstrates precise clinical efficacy in treating KOA patients.This treatment approach significantly reduces pain,enhances knee joint activity,promotes recovery of knee function,and improves daily living and walking abilities.
platelet rich plasmacompound betamethasoneknee osteoarthritisknee functionability of daily livingwalking ability
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