Changes in Distribution Characteristics and Drug Resistance of Gram-Negative Bacilli in a Tertiary Hospital in Chongqing from 2015 to 2019
Objective:To monitor the distribution and drug resistance of Gram-negative isolates from a hospital in Chongqing from 2015 to 2019.Methods:Specimens containing Gram-negative bacilli from a hospital in Chongqing submitted by Study for Monitoring Antimicrobial Resistance Trends(SMART)were used to perform antimicrobial susceptibility testing employing the custom sensitivity plate and Trek system.Results:A total of 950 Gram-negative isolates from patients with abdominal,respiratory,urinary,and bloodstream infections were collected.Among which,the detected Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa and Acinetobacter baumannii accounted for 43.37%,18.63%,14.11%and 10.84%,respectively.The resistance rates of Acinetobacter baumannii and Pseudomonas aeruginosa to conventional antimicrobials were high but without obvious changes from 2015 to 2019.The resistance rates of Klebsiella pneumoniae to third-generation cephalosporins and fluoroquinolones in 2017 increased significantly as compared with that in 2016,while the figure for resistance to carbapenems decreased to lower than 20%in 2019.In addition,there was a significant difference in the resistance rates of Gram-negative bacilli across infection sites.Among them,it was noted that high sensitivity rate of Acinetobacter baumannii obtained from urinary tract infection to both levofloxacin and colistin.However,in terms of abdominal and respiratory tract infections,the drug resistance rates were more than 50%.Fewer conventional antimicrobials are currently available for detected carbapenem-resistant Acinetobacter baumannii,cefotaxime-or ceftriaxone-resistant Escherichia coli,fluoroquinolone-resistant Escherichia coli,multidrug-resistant Acinetobacter baumannii,and multidrug-resistant Pseudomonas aeruginosa.Conclusion:The problem regarding the drug resistance of Gram-negative bacteria in the hospital from 2015 to 2019 was relatively prominent,particularly the third-generation cephalosporin-resistant germs in Enterobacterales order.The resistance rates of Acinetobacter baumannii to most antimicrobials is very high regardless of whether it is a special drug-resistant bacteria,which needs continuously monitoring and reference to clinical practice for reasonable selection of effective antimicrobials.
Gram-negative bacilligerms in Enterobacterales ordernon-fermentative Gram-negative bacilliantibacterial drugsdrug resistance
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维普
