Clinical Efficacy of Single Injection of Methotrexate in the Treatment of Tubal Pregnancy and its Effect on Serum β-Human Chorionic Gonadotropin,Placental Growth Factor and Vascular Endothelial Growth Factor
Objective:To investigate the clinical efficacy of single injection of methotrexate in the treatment of tubal pregnancy and its effect on serum β-human chorionic gonadotropin(β-HCG),placental growth factor(PLGF)and vascular endothelial growth factor(VEGF).Methods:A total of 80 patients with tubal pregnancy who were treated in a certain hospital from June 2019 to June 2021 were divided into the control group and the observation group according to the random number table method and the patients'fully informed consent and voluntary basis,with 40 patients in each group.All patients were in bed rest upon admission and closely monitored for changes in vital signs.The control group was treated with conventional fractional injections of methotrexate and the observation group was treated with single injection of methotrexate.The clinical efficacy,improvement time of clinical symptoms(abdominal pain,vaginal bleeding and pelvic mass),time for serum β-HCG returning to normal,length of hospital stay,hematological markers(β-HCG,progesterone,PLGF,VEGF),diameter of pelvic mass,adverse reactions and post-treatment fertility were compared between the two groups.Results:After treatment,the total response rate in the observation group(90.00%)was higher than that in the control group(72.50%,P<0.05).The time of improvement in clinical symptoms and the recovery time of serum β-HCG in the observation group were shorter than those in the control group(P<0.05).There was no statistically significant difference in the length of hospital stay between the two groups(P>0.05).Serum levels of β-HCG,PLGF,VEGF,progesterone and pelvic mass diameter were decreased in two groups(P<0.05),and observation group was lower than control group(P<0.05).The total incidence of adverse reactions in the observation group(17.50%)was lower than that in the control group(37.50%,P<0.05).There was no statistically significant difference in the intrauterine pregnancy rate between the two groups(χ2=0.503,P=0.478).Conclusion:The single injection of methotrexate in the treatment of tubal pregnancy showed definite clinical efficacy as demonstrated by effectively improved clinical symptoms,reduced serum levels of β-HCG,PLGF and VEGF,without additional risks of adverse reactions.
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