The Effect of Shensong Yangxin Capsule Combined with Rosuvastatin Calcium Tablets on the Occurrence of Arrhythmia Episodes and Vascular Elasticity in Elderly Patients with Coronary Heart Disease Accompanied with Arrhythmia
Objective:To investigate the effects of Shensong Yangxin capsule in combination with rosuvastatin calcium tablets on the occurrence of arrhythmia episodes and vascular elasticity in elderly patients with coronary heart disease accompanied with arrhythmia.Methods:110 elderly patients with coronary heart disease accompanied with arrhythmia admitted to the Department of Cardiology of a hospital from February 2021 to January 2023 were selected as the study subjects,and were assgined into the control group and the observation group using a random number table method,with 55 cases in each group.Both groups received standard western medical treatment,the control group was given oral rosuvastatin calcium tablets in addition to the standard treatment,and the observation group was given oral Shensong Yangxin capsule in addition to the treatment received by the control group,and both groups were treated for 4 weeks.The clinical efficacy,the occurrence of arrhythmia episodes(ventricular premature beat,atrial premature beat,premature junctional complex,and short bursts of atrial fibrillation),the vascular elasticity indexes[brachial-ankle pulse wave velocity(baPWV),carotid-femoral pulse wave velocity(cfPWV)],ankle brachial index(ABI)],traditional Chinese medicine(TCM)syndrome score,left ventricular ejection fraction(LVEF),brain natriuretic peptide(BNP),cardiac troponin I(cTnI),CXC chemokine ligand 16(CXCL16),high-sensitivity C-reactive protein(hs-CRP)and the occurrence of adverse reactions were compared between the two groups.Results:Following treatment,the overall response rate in the observation group(94.55%)was higher than that in the control group(81.82%,P<0.05).The frequency of ventricular premature beat,atrial premature beat,premature junctional complex,and short bursts decreased in both groups(P<0.05),with a more significant reduction in the observation group compared to the control group(P<0.05);the cfPWV and baPWV decreased in both groups(P<0.05),with a more significant reduction in the observation group compared to the control group(P<0.05);the ABI increased in both groups(P<0.05),with a more significant increase in the observation group compared to the control group(P<0.05);the TCM syndrome score decreased in both groups(P<0.05),with a more significant reduction in the observation group compared to the control group(P<0.05);the LVEF increased in both groups(P<0.05),with a more significant increase in the observation group compared to the control group(P<0.05);the BNP,cTnI,CXCL16 and hs-CRP decreased in both groups(P<0.05),with a more significant reduction in the observation group compared to the control group(P<0.05).No serious adverse reactions occurred in both groups during treatment.Conclusion:Clinical efficacy of Shensong Yangxin capsule in combination with rosuvastatin calcium tablets in the treatment of elderly patients with coronary heart disease accompanied with arrhythmia can effectively improve patients'vascular elasticity,reduce the occurrence of arrhythmia episodes,and lower the levels of BNP,cTnI,CXCL16,and hs-CRP.
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