Investigation and Analysis of Skin Allergy Tests and Cross Allergy Warning of 32 Cephalosporin Antibacterial Drugs Based on Drug Package Inserts
Objective:To collect the drug package inserts of cephalosporins marketed in China,and explore the problems currently existing in the use of cephalosporin antibacterial drugs.Methods:The catalogue of cephalosporin antibacterial drugs marketed in China was obtained from the official website of the National Medical Products Administration(NMPA),and the drug package inserts listed in the target drug catalogue were collected from the database of MCDEX software(web version),medication assistant software(mobile version)and yaoZh data,etc.,and the contents involved the skin allergy test requirement and cross allergy warning were classified and summarized for analysis.Results:A total of 3579 package inserts for 267 products of 32 cephalosporin antibacterials that met the inclusion criteria were collected;311 package inserts emphasized the requirement or recommendation of skin allergy test before use;each package insert contained a warning of cross-allergy,but the descriptions were different.Most of the drugs had history of cephalosporin allergy as a prohibited condition in the contraindication section,while some cephalosporins had penicillin allergy as a prohibited condition in the package inserts.Conclusion:At present,there are still divergence in the labelling of skin tests in the package inserts of cephalosporin antibacterial drugs in China;the description of[Contraindication]is over-exaggerated for cross-allergy,which,to a certain extent,may cause some patients to lost the chance to receive penicillin and cephalosporins,which needs to be further standardized.
国家科技期刊平台
NSTL
万方数据
