Effects of Bushen Huoxue Formula Combined with Estradiol Tablets/Estradiol and Dydrogesterone Tablets on Traditional Chinese Medicine Syndrome,Ovarian Reserve Function and T Cell Subsets in Patients with Premature Ovarian Failure
Objective:To investigate the clinical efficacy of Bushen Huoxue formula combined with estradiol tablets/estradiol and dydrogesterone tablets in the treatment of premature ovarian failure(POF)and its effects on traditional Chinese medicine(TCM)syndrome scores,ovarian reserve function and T cell subsets.Methods:A total of 90 patients with POF who visited a hospital from December 2020 to June 2022 were selected and divided into the western medicine group,TCM group and combination group by random number table method,with 30 patients in each group.The western medicine group was treated with complex packing estradiol tablets/estradiol and dydrogesterone tablets,the TCM group with Bushen Huoxue formula,and the combination group with Bushen Huoxue formula combined with complex packing estradiol tablets/estradiol and dydrogesterone tablets.All groups were treated for 3 cycles.The TCM syndrome scores,sex hormone levels[follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2)],ovarian reserve function(endometrial thickness,antral follicle count,ovarian volume),T cell subsets(CD3+,CD4+,CD8+),clinical response and adverse reactions were compared among the three groups.Results:After treatment,the TCM syndrome scores were decreased in both groups(P<0.05),and were lower in the combination group than those in the other two groups(P<0.05).The levels of FSH and LH were decreased in both groups(P<0.05),and were lower in the combination group than those in the other two groups(P<0.05).The level of E2 was increased in both groups(P<0.05),and was higher in the combination group than that in the other two groups(P<0.05).Endometrial thickness,antral follicle count and ovarian volume were increased in both groups(P<0.05),and were higher in the combination group than those in the other two groups(P<0.05).The levels of CD3+and CD8+were decreased in both groups(P<0.05),and were lower in the combination group than those in the other two groups(P<0.05).The level of CD4+was increased in both groups(P<0.05),and was higher in the combination group than that in the other two groups(P<0.05).The total response rate in the combination group(90.00%)was higher as compared with the western medicine(60.00%)and the TCM groups(76.67%,P<0.05).No significant adverse reactions were observed in any of the three groups during the treatment.Conclusion:Bushen Huoxue formula combined with estradiol tablets/estradiol and dydrogesterone tablets has satisfactory clinical efficacy in the treatment of patients with POF as demonstrated by effectively relieved clinical symptoms and improved sex hormone levels,ovarian reserve function and immune function.
premature ovarian failureBushen Huoxue formulaestradiol tablets/estradiol and dydrogesterone tabletstraditional Chinese medicine syndromeovarian reserve functionT cell subsets
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