Resistance Patterns and Rational Drug Use in Gram-Negative Bacterium in Intra-Abdominal Infections in a Tertiary Hospital in Beijing from 2014 to 2019
Objective:To provide reference for epidemiology and resistance patterns of Gram-negative bacterium in intra-abdominal infections in recent years by identification and testing of susceptibility to commonly used antibiotics using Gram-negative isolates from intra-abdominal infection collected from a tertiary hospital in Beijing from 2014 to 2019.Methods:Antimicrobial susceptibility testing was performed using the Trek system,and the susceptibility interpretation was performed according to the CLSI 2021.Results:From 2014 to 2019,a total of 464 Gram-negative bacterial isolates were collected,including 355 isolates of Enterobacteriaceae,123 isolates from community-acquired infections,341 isolates from hospital-acquired infections and 187 isolates from ICU.The results of susceptibility testing showed that among carbapenem-resistant bacterium in this hospital,Escherichia coli strains were not susceptible to 12 antibiotics which are currently commonly used in China,with the only susceptibility identified with amikacin,and its susceptible rate was 81.8%;There are few available alternative antibiotics for Klebsiella pneumoniae except colistin;At present,the susceptibility rates of ciprofloxacin,cefepime and amikacin to Pseudomonas aeruginosa were all 75.0%.For the quinolone-resistant bacterium in this hospital,ertapenem,imipenem,meropenem,amikacin and colistin were the antibiotics with an effective rate of over 82.5%against Escherichia coli.The susceptibility rates of imipenem,meropenem and amikacin to Klebsiella pneumoniae were only about 65.0%.For Pseudomonas aeruginosa,the available antibiotics were ceftazidime,cefepime and amikacin(susceptibility rate of 66.7%each).Among the third generation cephalosporin-resistant strains,the susceptibility rates were above 93.0%for imipenem,meropenem,amikacin and colistin against Escherichia coli,ranged from 71.4%to 79.2%for imipenem,meropenem and amikacin against Klebsiella pneumoniae,and were over 83.3%for ciprofloxacin,meropenem,amikacin and colistin against Pseudomonas aeruginosa.For any of carbapenem-resistant,quinolone-resistant or third-generation cephalosporin-resistant Acinetobacter baumannii,there are few available common antibiotics except colistin,which exhibited a susceptibility rate of 97.6%to 100%.Conclusion:The overall drug resistance of Gram-negative bacterium in intra-abdominal infections is severe,hence it is of great importance to continuously monitor the detection rate of pathogens in local hospitals and select effective antibiotic therapy for drug-resistant strains.
Gram-negative bacteriumgerms in enterobacterales ordernon-fermentative Gram-negative bacteriumantibioticsdrug resistance
万方数据
维普
