首页|河南某肿瘤医院临床分离菌分布及耐药性分析

河南某肿瘤医院临床分离菌分布及耐药性分析

扫码查看
目的:分析河南某肿瘤医院临床分离菌的分布及耐药性,为临床合理用药提供依据.方法:采用WHONET 5.6软件,分析2019年1月~2021年12月期间该院临床分离的所有细菌分布情况及耐药性.结果:共收集非重复菌株14 769株,其中革兰阴性菌9863株(66.8%),革兰阳性菌4906株(33.2%).标本以呼吸道(4295株,29.1%)、无菌体液(4093株,27.7%)和血液(2576株,17.4%)为主,科室分布以血液科(3134株,21.2%)、胃肠外科(1737株,11.8%)、肝胆外科(1703株,11.5%)、骨科(956株,6.5%)和重症医学病房(ICU,808株,5.5%)为主.耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)3年的检出率依次为35.5%(175/493)、36.4%(176/483)、41.2%(206/500)和78.8%(246/312)、65.6%(231/352)、61.7%(227/368).屎肠球菌对多数抗菌药物的耐药率均高于粪肠球菌.大肠埃希菌对碳青霉烯类仍高度敏感,3年的耐药率均低于5.0%.肺炎克雷伯菌对亚胺培南和美罗培南3年的耐药率呈下降趋势.铜绿假单胞菌对大多数抗菌药物的耐药率均低于鲍曼不动杆菌.ICU和血液科多重耐药菌的检出率较高.结论:该院2019年1月~2021年12月期间肿瘤患者临床分离菌株以革兰阴性杆菌为主,多重耐药菌除MRSA和 CRPA有所上升外,其他均呈下降趋势,应继续加强医院感染防控,重视细菌耐药监测.
Distribution and Drug Resistance Analysis of Clinical Bacterial Isolates Collected from a Henan Tumor Hospital
Objective:To analyze the distribution and drug resistance of clinical bacterial isolates in a Henan tumor hospital so as to provide the basis for clinical rational drug use.Methods:WHONET 5.6 software was used to analyze the distribution and drug resistance of all the bacterial isolates collected from a hospital during the period of January 2019 to December 2021.Results:A total of 14 769 non-repetitive strains were collected,including 9863(66.8%)strains of Gram-negative bacterial and 4906(33.2%)strains of Gram-positive bacterial.The strains were mainly isolated from specimens of respiratory tract(4295 strains,29.1%),sterile body fluids(4093 strains,27.7%)and blood(2576 strains,17.4%),and primarily distributed in the hematology department(3134 strains,21.2%),gastrointestinal surgery(1737 strains,11.8%),hepatobiliary surgery(1703 strains,11.5%),orthopedics(956 strains,6.5%)and intensive care unit(ICU)(808 strains,5.5%).The detection rates in the three years for methicillin-resistant Staphylococcus aureus(MRSA)were 35.5%(175/493),36.4%(176/483),and 41.2%(206/500),respectively,and 78.8%(246/312),65.6%(231/352)and 61.7%(227/368)for methicillin-resistant coagulase-negative Staphylococci(MRCNS).Enterococcus faecium showed a higher resistance rate against most antibiotics as compared with Enterococcus faecalis.Escherichia coli was still highly sensitive to carbapenems,and the resistance rates in all three years were lower than 5.0%.The drug resistance rates of Klebsiella pneumoniae against imipenem and meropenem were declining over 3 years.The resistance rate of Pseudomonas aeruginosa against most antimicrobials was lower than that of Acinetobacter baumannii.The detection rate of multi-drug resistant bacterial in ICU and hematology department was higher.Conclusion:Gram-negative bacilli were the main isolates collected from tumor patients in the hospital from January 2019 to December 2021,and there was a decreasing trend in all multi-drug resistant bacterial with the exception of MRSA and CRPA which showed an increasing trend.It is necessary to strengthen the prevention and control of nosocomial infection and pay attention to the monitoring of bacterial resistance.

bacterial distributiontumor patientsdrug resistance rateStaphylococcus aureusPseudomonas aeruginosa

屈元晔、肖伟强、常彦敏、孙明月、王小昆、许青霞

展开 >

郑州大学附属肿瘤医院检验科,郑州 450000

细菌分布 肿瘤患者 耐药率 金黄色葡萄球菌 铜绿假单胞菌

2024

中国合理用药探索
中国执业药师协会

中国合理用药探索

影响因子:0.62
ISSN:2096-3327
年,卷(期):2024.21(7)