Distribution and Drug Resistance Analysis of Clinical Bacterial Isolates Collected from a Henan Tumor Hospital
Objective:To analyze the distribution and drug resistance of clinical bacterial isolates in a Henan tumor hospital so as to provide the basis for clinical rational drug use.Methods:WHONET 5.6 software was used to analyze the distribution and drug resistance of all the bacterial isolates collected from a hospital during the period of January 2019 to December 2021.Results:A total of 14 769 non-repetitive strains were collected,including 9863(66.8%)strains of Gram-negative bacterial and 4906(33.2%)strains of Gram-positive bacterial.The strains were mainly isolated from specimens of respiratory tract(4295 strains,29.1%),sterile body fluids(4093 strains,27.7%)and blood(2576 strains,17.4%),and primarily distributed in the hematology department(3134 strains,21.2%),gastrointestinal surgery(1737 strains,11.8%),hepatobiliary surgery(1703 strains,11.5%),orthopedics(956 strains,6.5%)and intensive care unit(ICU)(808 strains,5.5%).The detection rates in the three years for methicillin-resistant Staphylococcus aureus(MRSA)were 35.5%(175/493),36.4%(176/483),and 41.2%(206/500),respectively,and 78.8%(246/312),65.6%(231/352)and 61.7%(227/368)for methicillin-resistant coagulase-negative Staphylococci(MRCNS).Enterococcus faecium showed a higher resistance rate against most antibiotics as compared with Enterococcus faecalis.Escherichia coli was still highly sensitive to carbapenems,and the resistance rates in all three years were lower than 5.0%.The drug resistance rates of Klebsiella pneumoniae against imipenem and meropenem were declining over 3 years.The resistance rate of Pseudomonas aeruginosa against most antimicrobials was lower than that of Acinetobacter baumannii.The detection rate of multi-drug resistant bacterial in ICU and hematology department was higher.Conclusion:Gram-negative bacilli were the main isolates collected from tumor patients in the hospital from January 2019 to December 2021,and there was a decreasing trend in all multi-drug resistant bacterial with the exception of MRSA and CRPA which showed an increasing trend.It is necessary to strengthen the prevention and control of nosocomial infection and pay attention to the monitoring of bacterial resistance.