Comparison of the Effect of Antibiotic-Loaded Absorbable Calcium Sulfate and Biological Bone Cement Chain Bead Membrane Induction in Children with Heel Tissue Defect Complicated with Traumatic Calcaneal Osteomyelitis
Objective:To investigate the effect of antibiotic-loaded absorbable calcium sulfate versus biological bone cement chain bead membrane induction in children with heel tissue defect complicated with traumatic calcaneal osteomyelitis.Methods:A total of 96 children with heel tissue defect complicated with traumatic calcaneal osteomyelitis treated in a hospital from January 2018 to December 2022 were selected and divided into control group(n=54)and observation group(n=42)according to the surgical procedure.The control group was treated with reasonable flap repair combined with biological bone cement chain bead membrane induction,and the observation group was treated with reasonable flap repair combined with antibiotic-loaded absorbable calcium sulfate.Bacterial culture of wound secretion,infection indicators[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),white blood cell count(WBC),erythrocyte sedimentation rate(ESR)],visual analogue scale(VAS)score,duration of hospitalization,healing time,complications,infection recurrence rate and reoperation situation were compared between the two groups.Results:The results of bacterial culture of wound secretion showed that Staphylococcus aureus was the predominant bacteria in both groups.The WBC,ESR,IL-6,IL-8 and TNF-α were decreased in both groups at 7 days and 14 days after operation(P<0.05),and were lower in the observation group compared with the control group(P<0.05).The VAS score was decreased in both groups at 1,3 and 6 months after operation(P<0.05),and was lower in the observation group compared with the control group at 1 and 3 months after operation(P<0.05).There was no statistically significant difference in the VAS score at 6 months after operation between the two groups(P>0.05).The duration of hospitalization and healing time in the observation group were shorter than those in the control group(P<0.05).There was no statistically significant difference in the total incidence of complications and the infection recurrence rate of 6 months after operation between the two groups(P>0.05).In the control group,bone cement chain beads needed to be removed again,and 9 of them received bone cement implantation again.Conclusion:Reasonable flap repair combined with antibiotic-loaded absorbable calcium sulfate can effectively relieve pain,inhibit inflammatory reaction,and promote postoperative rehabilitation and bone healing in children.
万方数据
维普
