Pharmaceutical Monitoring of Vancomycin-Induced Leukopenia and Neutropenia
Objective:To report and analyze the adverse reactions of leukopenia and neutropenia in one patient after using vancomycin,and to provide reference for rational and safe clinical use.Methods:The clinical pharmacist's participation in the case of leukopenia and neutropenia induced by vancomycin which was administered to treat incision infection following the surgery for developmental dysplasia of the left hip in an elderly patients was analyzed.The Naranjo assessment scale and literature were used to assess the relationship between the adverse reactions and vancomycin as well as the treatment measures.Results:The clinical pharmacist advised to discontinue vancomycin upon the occurrence of leukopenia and neutropenia.The patient's leukocytes and neutrophils recovered to normal 4 days after vancomycin discontinuation.The score based on the Naranjo assessment scale was 5 points and the relationship was assessed as"probably"related.Conclusion:The participation of clinical pharmacists in the whole process of clinical medication can help clinicians to identify adverse drug reactions,warn to pay attention to the leukopenia and neutropenia caused by the use of vancomycin in patients,and guarantee the safety and efficacy of drug use in patients.
vancomycinleukopenianeutropeniaadverse drug reactionclinical pharmacist
万方数据
维普
