Analysis of the Use of"New Quadruple"Drugs in Outpatients with Chronic Heart Failure
Objective:To analyze the prescription of patients with chronic heart failure in outpatient department of a hospital and investigate the utilization of"new quadruple"drug regimens to promote the rational use of medications.Methods:Prescriptions for patients diagnosed with chronic heart failure in the outpatient department of cardiovascular medicine from January to May 2024 were selected using a prescription automatic screening system,and analyze the utilization of"new quadruple"drug combinations,drug selection patterns and achievement of target doses.Results:"New quadruple"drug prescriptions accounted for 63.50%of the prescriptions for chronic heart failure,involving a total of 3079 patients.Among"new quadruple"drug prescriptions,65.37%consisted of single"new quadruple"regimens;Combination prescriptions included angiotensin Ⅱ receptor-neprilysin inhibitor(ARNI)/angiotensin converting enzyme inhibitor(ACEI)/angiotensin Ⅱ receptor blocker(ARB)+β-blocker(βB),accounted for 47.74%of the two-drug prescriptions;Triple drug combinations accounted for 5.88%,while quadruple drug combinations only accounted for 0.49%.In the ARNI/ACEI/ARB group involving multiple drugs,sacubitril valsartan was overwhelmingly dominant(95.49%).Among the βB prescriptions,metoprolol was prescribed slightly more than bisoprolol.The highest compliance rate with target dose were observed in mineralocorticoid receptor antagonists(MRA)among the"new quadruple"drug.However,there is still a significant room for improvement in achieving target doses for ARNI/ACEI/ARB and βB.Conclusion:At present,there is a certain gap between the utilization of"new quadruple"drug regimens and the achievement of target doses among the outpatients with chronic heart failure in the hospital and the guideline-directed medical therapy.Clinical pharmacists should strengthen cooperation with physicians to promote the rational use of medications,to ensure drug safety and improve life quality of patients with chronic heart failure.
chronic cardiac failurenew quadruplemedication useoutpatient prescriptionrational drug use
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