Effects of Edaravone Dexborneol Combined with Urinary Kallidinogenase on Neurological Function and Serum Free Radical-Related Indexes in Patients with Progressive Cerebral Infarction
Objective:To observe the effect of edaravone dexborneol combined with urinary kallidinogenaseon neurological function and serum free radical-related indexes in patients with progressive cerebral infarction.Methods:A total of 108 patients with progressive cerebral infarction who visited the neurology department of a hospital from October 2020 to October 2023 were selected as the study subjects,and divided into control group and observation group according to simple random method,with 54 patients in each group.The two groups were both given symptomatic treatment,the control group was treated with edaravone dexborneol,and the observation group was treated with edaravone dexborneol combined with urinary kallidinogenase.The clinical efficacy,ischemic hypoperfusion area,free radical-related indexes[malondialdehyde(MDA),reactive oxygen species(ROS),and superoxide dismutase(SOD)],nerve-related factors[neuron specific enolase(NSE),brain-derived neurotrophic factor(BDNF),S100B protein,and amyloid β-protein 1-42(Aβ 1-42)],National Institutes of Health stroke scale(NIHSS)score,Barthel index(BI)score and adverse reactions were compared between the two groups.Results:After treatment,the total response rate of the observation group was higher than that of the control group(P<0.05);The ischemic hypoperfusion area,MDA,ROS,NSE,S100B protein,Aβ 1-42 and NIHSS score were decreased as compared with those before treatment in both groups and lower in the observation group than those in the control group(P<0.05).SOD,BDNF and BI score were increased in both groups as compared with those before treatment and higher in the observation group than those in the control group(P<0.05).No statistically significant difference was observed in the total incidence of adverse reactions between the two groups during the study(P>0.05).Conclusion:Edaravone dexborneol combined with urinary kallidinogenase could reduce the nerve damage in patients with progressive cerebral infarction and improve the efficacy,which was possibly associated with scavenging oxygen free radicals and regulating nerve factors.
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