Clinical Study of Paracetamol and Tramadol Hydrochloride Combined with Ultrasound-Guided Paravertebral Nerve Block in the Treatment of Patients with Postherpetic Neuralgia
Objective:To explore the therapeutic effect of paracetamol and tramadol hydrochloride combined with ultrasound-guided paravertebral nerve block therapy on patients with postherpetic neuralgia(PHN).Methods:A total of 150 patients with PHN treated in the hospital from October 2022 to October 2023 were selected and divided into the control group and the observation group using the simple random grouping method,with 75 patients in each group.The patients in the control group received ultrasound-guided paravertebral nerve block,whereas the patients in the observation group were treated with paracetamol and tramadol hydrochloride tablets on the basis of the control group.The clinical efficacy,pain status[visual analogue scale(VAS)],sleep quality[Pittsburgh sleep quality index(PSQI)],serum pain mediators[neurotensin(NT),β-endorphin(β-EP)and substance P(SP)],complications and adverse reactions were compared between the two groups.Results:After treatment,the overall response rate in the observation group(84.00%)significantly higher than in the control group(62.67%,P<0.05).The VAS scores,PSQI scores and SP level were decreased in both groups,and the observation group were lower than those in the control group(P<0.05).The levels of serum NT and β-EP were increased in both groups,and the observation group were higher than those in the control group(P<0.05).During the treatment period,no complications resulting from the procedure,such as nerve injury,infection,pneumothorax,needle puncture into blood vessels,and addiction to paracetamol and tramadol hydrochloride,were reported in either group.The overall incidence rate of adverse reactions in the observation group(36.00%)was lower than in the control group(70.67%,P<0.05).Conclusion:Paracetamol and tramadol hydrochloride combined with ultrasound-guided paravertebral nerve block demonstrated positive clinical efficacy in the treatment of PHN patients.This treatment can effectively improve pain and sleep quality,regulate pain-related mediator levels,and reduce the occurrence of adverse reactions.
paracetamol and tramadol hydrochlorideultrasound-guided paravertebral nerve blockpostherpetic neuralgiapain-related mediatorsleep quality
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维普
