Analysis of 99 Serious Adverse Drug Reaction/Event Associated with Anti-Infective Agents
Objective:To analyze the characteristics and rules of serious adverse drug reaction/event(ADR/ADE)associated with anti-infective agents,and provide references for the promotion of rational clinical use of these medications.Methods:99 serious ADR/ADE reports associated with anti-infection agents reported by a hospital to the National Adverse Drug Reaction Monitoring Center between 2010 and 2022 were selected and analyzed statistically.Results:In the 99 serious ADR/ADE,the male-to-female patient ratio was 1.7:1.Patients aged over 60 experienced the highest incidences(21.2%).12 patients had a previous history of drug allergy.The primary route of administration was intravenous infusion(53.5%).The study involved 13 major categories and 37 types of anti-infective agents,with the highest frequency of reports associated with anti-tuberculosis drugs(60.2%).Notably,pyrazinamide and rifampin rank highest for ADR/ADE incidence(15.1%).The system organ class involved was mainly skin and appendages disorders(19.1%).Conclusion:For clinical application of anti-infective agents,besides anti-infective efficacy,we should also be alert to the potential drug safety issues,especially serious adverse drug reactions ADR/ADE.Effective measures should be formulated to lower the incidence of ADR/ADE to anti-infective agents.
anti-infective agentsserious adverse drug reaction/eventrational drug usesafe drug useanalysis of reports
万方数据
维普
