Effects of Xuezhikang Capsules Combined with Metoprolol Succinate on Cardiac Function,Lipid Metabolism and Hemorheology in Patients with Chronic Cardiac Failure Complicated with Hyperlipidaemia
Objective:To investigate the effects of Xuezhikang capsules combined with metoprolol succinate on cardiac function,lipid metabolism and hemorheology in patients with chronic cardiac failure complicated with hyperlipidaemia.Methods:A total of 105 patients with chronic cardiac failure complicated with hyperlipidaemia treated in a hospital from February 2021 to February 2024 were selected and assigned to the control group (52 enrolled,with 1 patient excluded due to unauthorized change of dosage regimen) and observation group (53 enrolled,with 1 patient excluded due to complication of stroke and 1 patient excluded due to unauthorized dose change) by envelopes method,resulting in 51 patients enrolled in each group.Both groups were given conventional treatment.The control group was treated with metoprolol succinate extended-release tablets,and the observation group was treated with Xuezhikang capsules on the basis of the control group.Serum lipid parameters[low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C),total cholesterol (TC),triglyceride (TG)],N-terminal pro-brain natriuretic peptide (NT-proBNP),proprotein convertase subtilisin/kexin type 9 (PCSK9),C-reactive protein (CRP),hemorheology,cardiac failure (Lee's heart failure score),cardiopulmonary function (6 min walking distance),cardiac function[left ventricular end-systolic diameter (LVESD),left ventricular end-diastolic diameter (LVEDD),left ventricle ejection fraction (LVEF)]and medication safety were compared between the two groups.Results:After treatment,HDL-C,6 min walking distance and LVEF were increased,and the observation group were higher than in the control group.LDL-C,TC,TG,NT-proBNP,CRP,whole blood viscosity at high shear rate,whole blood viscosity at low shear rate,plasma viscosity,fibrinogen,Lee's heart failure score,LVESD and LVEDD were decreased and the observation group were lower than in the control group (P<0.05).During the treatment,the hepatic and renal function and hematology were normal in the two groups,and there were no serious adverse reactions.Conclusion:Xuezhikang capsules combined with metoprolol succinate shows significant efficacy in the treatment of patients with chronic cardiac failure complicated with hyperlipidaemia,regulating serum lipid,and improving cardiac function and hemorheology,with a high safety profile.
万方数据
维普
