Effect of Sodium Tanshinone ⅡA Sulfonate Combined with Metoprolol Tartrate on Cardiac Function and Micro-Inflammatory Status in Patients with Unstable Angina Pectoris
Objective:To explore the effect of sodium tanshinone ⅡA sulfonate combined with metoprolol tartrate on cardiac function and micro-inflammatory status in patients with unstable angina pectoris (UAP).Methods:A total of 126 UAP patients treated in a hospital from 1 February 2021 to 31 October 2023 were selected and assigned to the control group and observation group by random number table,with 63 patients in each group.Apart from conventional treatment,the control group was additionally given metoprolol tartrate tablets,while the observation group was given tanshinone ⅡA sulfonate sodium injection in addition to the control treatment.The clinical symptoms (frequency of angina attacks,duration of angina pectoris,heart rate),cardiac function[left ventricular ejection fraction (LVEF),left ventricular end-systolic diameter (LVESD),left ventricular end-diastolic diameter (LVEDD)],vascular endothelial function[nitric oxide (NO),endothelin-1 (ET-1),flow-mediated diameter (FMD)]and inflammatory indicators[C1q tumor necrosis factor-related protein 1 (CTRP1),interleukin-17A (IL-17A),tumor necrosis factor-α (TNF-α)]and clinical efficacy were compared between the two groups,as well as the occurrence of adverse reactions during treatment.Results:After treatment,the frequency of angina attacks,duration of angina,LVESD,LVEDD,ET-1,CTRP1,IL-17A,and TNF-α in both groups of patients decreased,and the observation group was lower than the control group (P<0.05);LVEF,NO,and FMD all increased,and the observation group was higher than the control group (P<0.05).The total effective rate of treatment in the observation group (92.06％) was higher than that in the control group (79.37％,P<0.05).No statistically significant difference was observed in the total incidence of adverse reactions between the two groups during the study (P>0.05).Conclusion:Sodium tanshinone ⅡA sulfonate combined with metoprolol tartrate can increase the clinical efficacy,enhance cardiac function and vascular endothelial function,reduce inflammatory reaction without increasing risk of adverse reactions in patients with UAP.
unstable angina pectorissodium tanshinone ⅡA sulfonatemetoprolol tartratecardiac functionmicro-inflammatory status
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维普
