Effect of Intravenous Flumazenil on the Quality of Recovery in Patients Undergoing Hysteroscopic Surgery under Total Intravenous Anesthesia with Nasopharyngeal Ventilation
Objective:To investigate the effect of intravenous flumazenil on the quality of recovery in patients undergoing hysteroscopic surgery under total intravenous anesthesia with nasopharyngeal ventilation.Methods:A total of 92 patients who underwent hysteroscopic surgery in a hospital from July 2021 to February 2024 were selected and assigned to the control group and observation group by random number table method,with 46 patients in each group.The control group was given total intravenous anesthesia (remimazolam besylate for injection combined with oxycodone hydrochloride injection),while the observation group was additionally given flumazenil injection at the end of surgery.The recovery time,orientation recovery time,sedation effect (Ramsay score),stress response[norepinephrine (NE),epinephrine (E),cortisol (Cor) levels],pain condition[visual analogue scale (VAS)]and adverse reactions were compared between the two groups.Results:The recovery time and orientation recovery time of the observation group was shorter than that of the control group (P<0.05).The sedation effect of observation group was better than that of control group (P<0.05).There was no statistically significant difference in NE,E and Cor levels between the two groups at 24h following surgery (P>0.05).There was no statistically significant difference in VAS scores between the two groups at 2h,6h,12h and 24h after surgery (P>0.05).There was no statistically significant difference in the total incidence of adverse reactions such as somnolence,nausea and vomiting,dizziness and bradycardia between the two groups (P>0.05).Conclusions:Intravenous flumazenil can promote anesthesia awakening and recovery in patients who underwent hysteroscopic surgery under total intravenous anesthesia with nasopharyngeal ventilation,without affecting stress response levels and postoperative pain levels,and without increasing the risk of adverse reactions.
万方数据
维普
