目的:分析国内外双硫仑样反应研究领域中的研究热点及前沿趋势,以期为研究人员提供新思路和新方向.方法:检索1994年至 2024年1月期间中国知网(CNKI)、Web of Science和PubMed数据库收录的双硫仑样反应相关文献,并采用CiteSpace 6.3.R6软件对文献进行可视化分析.结果:共检索到文献1047篇,其中91篇英文文献、956篇中文文献.英文文献发文量随时间无明显变化,中文文献2011年发文量最高,随后逐年减少.研究国家/机构共现结果显示,不同国家/机构间尚未形成成熟的合作网络,研究较分散.D,Faiman M和李成建分别为英文文献和中文文献发文量最多的作者.关键词分析结果表明,既往研究主要集中在双硫仑样反应现象本身和机制研究,涉及的关键词包括双硫仑、头孢菌素等;目前研究热点主要转向急救护理,涉及的关键词包括护理、纳洛酮等.结论:随着药物研发进展和研究的不断深入,双硫仑样反应现象已被公众认知,研究方向主要集中在发生机制、临床表现、预防和治疗方面,但仍有部分问题尚不明确,如乙醇与双硫仑样反应的剂量-效应、法医学诊断等仍需进一步研究.
Research Hotspots and Frontier Trends Analysis of Disulfiram-Like Reaction Based on Bibiometric
Objective:To analyze the research hotspots and frontier trends in the field of disulfiram-like reaction both domestically and internationally,in order to provide new ideas and directions for researchers.Methods:The literatures on disulfiram-like reaction collected from CNKI,Web of Science and PubMed from 1994 to January 2024 were retrieved and visualized by CiteSpace 6.3.R6 software.Results:A total of 1047 literatures were retrieved,including 91 in English and 956 in Chinese.The number of published English literature did not change significantly over time,while the number of published Chinese literature peaked in 2011 and subsequently declined annually.The co-occurrence results of the research countries/institutions indicated that mature cooperation networks have not yet formed among different countries/institutions,and the research remains fragmented.D,Faiman M and Li Chengjian were the authors who published the most papers in English and Chinese literatures,respectively.The results of keyword analysis revealed that previous studies mainly focused on the disulfiram-like reaction phenomenon and mechanism research,involving keywords including disulfiram,cephalosporin,etc.At present,the research focus shifted primarily to emergency nursing,with keywords including nursing,naloxone and so on.Conclusion:With the advancement of drug research and development and deepening of research,the phenomenon of disulfiram-like reaction has gained public recognition,and the research direction mainly focuses on pathogenesis,clinical manifestations,prevention and treatment.However,several unsolved issues remained,such as the dose-effect relationship of ethanol reaction with disulfiram and forensic diagnosis,which warrants further research.
disulfiram-like reactionadverse drug reactionsbibliometricresearch hotspotsfrontier trends
万方数据
维普
