Isolation and Resistance Changes of Carbapenem-Resistant Acinetobacter baumannii in a Hospital from 2000 to 2021
Objective:To investigate the isolation and resistance changes resistance of carbapenem-resistant Acinetobacter baumannii(CRAB)in a hospital.Methods:Data from CRAB isolates collected in hospital between 2000 and 2021 were analyzed using WHONET5.6 software.Clinical data were retrieved from the hospital's laboratory information system for sorting and analysis.Results:A total of 3692 CRAB strains were obtained,with 62.5% originating from the intensive care unit(ICU)and 79.6% isolated from lower respiratory tract specimens.The detection rates of CRAB varied significantly over time and can be categorized into four distinct stages:during the trough period from 2000 to 2006,fewer than 10 strains were detected annually;during the climbing period from 2007 to 2011,an average of approximately 113 strains were detected per year;during the peak period from 2012 to 2017,the average increased to about 380 strains per year,accounting for 61.9% of the total detected cases;during the decline period from 2018 to 2021,there was a slight decrease,with an average of about 200 strains detected annually.The resistance rates of CRAB to commonly used clinical antibiotics are predominantly above 70.0%,with significant variations observed across different stages.The resistance rate of tigecycline ranged from 6.7% to 15.6%,while the resistance rates of amikacin and compound sulfamethoxazole have shown a decline.Conclusion:Despite a decrease in the current incidence of CRAB infections,the situation remains concerning.CRAB demonstratedsignificant resistance to commonly used antibiotics,necessitating strengthened hospital infection control measures,rational use of antibiotics,and enhanced multidisciplinary collaboration to prevent infections and mitigate drug resistance.
万方数据
维普
