Comparison of the Application of Letrozole Combined with Menotrophins Ovulation Induction Regimen Versus Artificial Cycle Regimen in Freeze-Thaw Single Blastocyst Transplantation in Infertile Patients with Polycystic Ovary Syndrome
Objective:To compare the efficacy of letrozole combined with menotrophins ovulation induction regimen versus artificial cycle regimen in freeze-thaw single blastocyst transplantation in infertile patients with polycystic ovary syndrome(PCOS).Methods:A total of 410 PCOS infertile patients admitted to a hospital from March 2021 to February 2024 were selected and divided into a control group and an observation group according to the endometrial preparation scheme,with 205 patients in each group.The control group was given artificial cycle regimen,while the observation group was given ovulation induction regimen of letrozole tablets combined with menotrophins for injection.Comparison of frozen-thawed embryos conditions(embryo freezing time,frozen embryo resuscitation rate),endometrial conditions(endometrial proliferation time,endometrial thickness on the day of endometrial transformation,type A endometrial rate),embryo transfer metrics(number of transplant cycles,cycle cancellation rate,high-quality blastocyst rate),laboratory indices on the day of transfer[estradiol(E2),progesterone(P)],pregnancy outcomes(early pregnancy P level,early pregnancy preeclampsia rate,early pregnancy spontaneous abortion rate,clinical pregnancy rate,blastocyst implantation rate)and metrics related to visits and deliveries(average number of visits,overall treatment costs,preterm birth rate,live birth rate,gestational duration,neonatal weight)were compared.Results:No statistically significant differences were observed in embryo freezing time,frozen embryo resuscitation rate,endometrial thickness on the day of endometrial transformation,type A endometrial rate,number of transplant cycles,cycle cancellation rate,high-quality blastocyst rate,P level,early pregnancy P level,clinical pregnancy rates,blastocyst implantation rate,early pregnancy spontaneous abortion rate,preterm birth rate,live birth rate,gestational duration and neonatal weight between the two groups(P>0.05).The endometrial proliferation time,early pregnancy preeclampsia rate and overall treatment costs in the observation group was significantly lower than that in the control group;E2 level and average number of visits in the observation group was significantly higher than that in the control group(P<0.05).Conclusion:Letrozole combined with menotrophins ovulation induction regimen offers greater advantages than artificial cycle regimen in the context of freeze-thawed single blastocyst transplantation in infertile patients with PCOS.This approach not only shortens the endometrial proliferation time,but also increases E2 level and reduces the overall treatment costs.
letrozole combined with menotrophins ovulation induction regimenartificial cycle regimenpolycystic ovary syndromefreeze-thaw single blastocyst transplantationendometrium
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