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白及汤治疗气阴两虚型肺结核的临床研究

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目的:探讨白及汤治疗气阴两虚型肺结核患者的临床疗效.方法:选取2021年 5 月~2023 年10 月期间某院收治的 74例气阴两虚型肺结核患者作为研究对象,采用随机数字表法分为对照组和观察组,每组 37 例.对照组接受常规西医治疗,观察组在对照组治疗基础上加用白及汤,两组均连续治疗6个月.比较两组患者中医证候积分、炎症指标[红细胞沉降率(ESR)、骨桥蛋白(OPN)]、病原学转阴情况、临床疗效及不良反应发生情况.结果:治疗后,两组患者中医证候积分、ESR和OPN水平均降低,且观察组低于对照组(P<0.05);观察组患者病原学转阴率(89.19%)高于对照组(70.27%,χ2=4.097,P=0.043);观察组患者治疗总有效率(91.89%)高于对照组(72.97%,P<0.05).治疗期间,两组患者不良反应总发生率比较无统计学差异(P>0.05).结论:白及汤治疗气阴两虚型肺结核患者临床效果较佳,可提高病原学转阴率,减轻炎症反应,且不会增加不良反应的发生风险.
Clinical Study on Baiji Decoction in the Treatment of Pulmonary Tuberculosis of Qi-Yin Deficiency Syndrome
Objective:To investigate the clinical efficacy of Baiji decoction in the treatment of pulmonary tuberculosis of qi-yin deficiency syndrome.Methods:A total of 74 patients with pulmonary tuberculosis of qi-yin deficiency syndrome treated in a hospital from May 2021 to October 2023 were selected and assigned to the control group and observation group by random number table method,with 37 patients in each group.The control group was treated with conventional western medicine,and the observation group was treated with Baiji decoction in addition to the treatment given in the control group.The two groups were treated for 6 months.The traditional Chinese medicine(TCM)syndrome score,inflammatory index[erythrocyte sedimentation rate(ESR),osteopontin(OPN)],microbiological negativity conversion,clinical efficacy and adverse reactions were compared between the two groups.Results:After treatment,the TCM syndrome scores,ESR and OPN levels were decreased in the two groups,with the observation group showing lower scores than the control group(P<0.05).The microbiological negativity conversion rate in the observation group(89.19% )was higher than that in the control group(70.27%,χ2=4.097,P=0.043).The total response rate in the observation group(91.89% )was higher than that in the control group(72.97%,P<0.05).During the treatment period,there was no statistically significant difference in the incidence of adverse reactions was observed between the two groups(P>0.05).Conclusion:Baiji decoction shows better clinical efficacy in the treatment of pulmonary tuberculosis of qi-yin deficiency syndrome,improving the microbiological negativity conversion rate,reducing inflammatory response,without increasing the risk of adverse reactions.

Baiji decoctionpulmonary tuberculosisqi-yin deficiency syndromeinflammatory responseefficacy

张欣蕊、张慧

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河南省中医院药学部,郑州 450011

白及汤 肺结核 气阴两虚型 炎症反应 疗效

2024

中国合理用药探索
中国执业药师协会

中国合理用药探索

影响因子:0.62
ISSN:2096-3327
年,卷(期):2024.21(12)