Objective:To analyze the occurrence of adverse drug reactions(ADR)associated with iodixanol injection and to provide references for its rational and safe use.Methods:To collect the ADR reports of iodixanol injection submitted to the National Adverse Drug Reaction Monitonring Systerm from January 2019 to February 2024,and to conduct a retrospective analysis on related data such as patient gender,age,route of administration,time of occurrence,involved systems/organs,clinical manifestations,management and outcomes.Results:A total of 37 cases of ADR associated with iodixanol injection were identified,with an incidence rate of 0.3% in females compared 0.23% in males.The patient age was 11～91 years,with the highest number of ADR(11 cases)occurring in patients aged 61～71 years.The incidence of acute ADR within 1h following intravenous administration(13.51% )was higher than that following arterial administration(5.41% ).The involved systems/organs affected by ADR were mainly the skin and its accessories(77.78% ).The prognosis for all cases was favorable.Conclusion:Clinicians should exercise special caution in female patients,receiving intravenous iodixanol injection within 1h,and regarding skin-related adverse reactions.All patients across age groups receiving iodixanol injection should be monitored and protected clinically as necessary,with appropriate preventive and responsive measures implemented to enhance drug safety.
关键词
碘克沙醇注射液/药品不良反应/发生时间/累及系统/器官/处理与转归/防范措施
Key words
iodixanol injection/adverse drug reactions/time of occurrence/involved systems/organs/management and outcomes/preventive measures
维普
万方数据