Analysis of 37 Cases of Adverse Drug Reactions Associated with Iodixanol Injection
Objective:To analyze the occurrence of adverse drug reactions(ADR)associated with iodixanol injection and to provide references for its rational and safe use.Methods:To collect the ADR reports of iodixanol injection submitted to the National Adverse Drug Reaction Monitonring Systerm from January 2019 to February 2024,and to conduct a retrospective analysis on related data such as patient gender,age,route of administration,time of occurrence,involved systems/organs,clinical manifestations,management and outcomes.Results:A total of 37 cases of ADR associated with iodixanol injection were identified,with an incidence rate of 0.3% in females compared 0.23% in males.The patient age was 11～91 years,with the highest number of ADR(11 cases)occurring in patients aged 61～71 years.The incidence of acute ADR within 1h following intravenous administration(13.51% )was higher than that following arterial administration(5.41% ).The involved systems/organs affected by ADR were mainly the skin and its accessories(77.78% ).The prognosis for all cases was favorable.Conclusion:Clinicians should exercise special caution in female patients,receiving intravenous iodixanol injection within 1h,and regarding skin-related adverse reactions.All patients across age groups receiving iodixanol injection should be monitored and protected clinically as necessary,with appropriate preventive and responsive measures implemented to enhance drug safety.
iodixanol injectionadverse drug reactionstime of occurrenceinvolved systems/organsmanagement and outcomespreventive measures
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