Objective:Literatures of disulfiram-like reactions to traditional Chinese patent medicines were reviewed and analyzed,to improve the safety awareness against disulfiram-like reactions to traditional Chinese patent medicines containing alcohol.Methods:A search was performed with"disulfiram-like reaction(s)"as the key word in CNKI and Wanfang database to obtain literatures referencing"traditional Chinese patent medicines","antibiotics"and"disulfiram-like reaction(s)".The involved drugs and their dosage and alcohol content for the disulfiram-like reactions were compiled.Results:Disulfiram-like reactions occurred with traditional Chinese patent medicines including topical preparations,oral preparations and injections.Disulfiram-like reactions were reported at varying dosage and alcohol content of 0.014 to 10ml.Conclusion:Alcohol-containing traditional Chinese patent medicines should be used with caution and should not be used concomitantly with cephalosporins with or without methyltetrazole(MTT)group,nitroimidazoles,nitrofurans,sulfonylurea hypoglycemic drugs,chloramphenicol,ketoconazole,isoniazid,etc.
关键词
中成药/双硫仑样反应/乙醇/抗生素/甲硫四氮唑
Key words
traditional Chinese patent medicines/disulfiram-like reaction/ethanol/antibiotics/methyltetrazole
维普
万方数据