Exploration on the Mechanism of Zhuanggu Qiangjin Tablets in the Treatment of Senile Osteoporosis Based on Network Pharmacology and Molecular Docking Technology
Objective To explore the effective components and mechanism of Zhuanggu Qiangjin Tablets in the treatment of senile osteoporosis(SOP)by means of network pharmacology and molecular docking technology.Methods The active components and targets of Zhuanggu Qiangjin Tablets were screened by TCMSP,HERB,PubChem,SwissTargetPrediction and UniProt database;the related targets of SOP were obtained from DisGeNet,GeneCards and OMIM databases.Cytoscape 3.8.0 was used to construct the"disease-drug-component-intersection target"network.PPI network was constructed using STRING and Cytoscape 3.8.0.After that,R 4.2.0 was used for GO functional enrichment analysis and KEGG pathway enrichment analysis.Finally,the core active components with high moderate value was molecule-docked with the core targets.Results A total of 270 Zhuanggu Qiangjin Tablets related targets were obtained,433 SOP related targets and 61 drug SOP intersection targets were obtained;the core components primarily included quercetin,luteolin,and kaempferol,while the core targets involved TNF,IL6,AKT1,and VEGFA.GO biological processes mainly encompassed oxidative stress response,reproductive structure development,and reproductive system development.The enriched KEGG pathways were primarily associated with AGE-RAGE signaling pathway in diabetic complications,lipid and atherosclerosis,and fluid shear stress and atherosclerosis.Conclusion Zhuanggu Qiangjin Tablets may exert therapeutic effects on SOP by acting on targets such as TNF,IL6,AKT1,and VEGFA,thereby regulating immune response and cellular metabolism.
国家科技期刊平台
NSTL
万方数据
维普
