Study on the Mechanism of Modified Sanjie Tongmai Decoction for the Treatment of Atherosclerosis Based on Network Pharmacology
Objective To explore the potential mechanism of Modified Sanjie Tongmai Decoction for the treatment of atherosclerosis based on modified network pharmacological.Methods The active components and targets of modified Sanjie Tongmai Decoction were screened from TCMSP database;atherosclerosis related targets were collected through GeneCards,OMIM and DrugBank databases;the drug and the disease targets were cross mapped to obtain the treatment target;the STRING database were used for protein-protein interaction(PPI)network construction and key targets were screened through the Cytoscape 3.7.2 software.The online software DAVID was used for GO and KEGG enrichment analysis.Results Totally 85 active components from modified Sanjie Tongmai Decoction,648 potential targets,1 439 atherosclerotic disease related target and 131 cross targets were obtained by retrieving and screening;5 key active components of modified Sanjie Tongmai Decoction for atherosclerotic diseases were screened,including quercetin,luteolin,ginsenoside Rg2,tanshinone ⅡA,cryptotanshinone,etc.;PPI showed that the potential key targets were VEGFA,AKT1,STAT3,TNF,IL6 etc.;631 biological processes,104 molecular functions and 61 cell components were obtained by GO enrichment;KEGG pathway enrichment analysis obtained 153 results,including cancer pathway,lipid and atherosclerosis,PI3K-Akt signaling pathway,AGE-RAGE signaling pathway in diabetis complications,fluid shear stress and atherosclerosis.Conclusion This study preliminarily reveals the scientific connotation of modified Sanjie Tongmai Decoction for the treatment of atherosclerosis with multi components,multi targets and multi approaches,which can provide a basis for the clinical development and utilization of the decoction,and further deepen the theoretical understanding of"blood stasis can transform into water".
国家科技期刊平台
NSTL
万方数据
维普
