Discussion on the Scientific Connotation of Different Treatments for the Same Disease between Banxia Baizhu Tianma Decoction and Qianghuo Shengshi Decoction Based on Network Pharmacology
Objective To analyze the differences in composition,target and mechanism between Banxia Baizhu Tianma Decoction and Qianghuo Shengshi Decoction using network pharmacology;To preliminarily elucidate the connotation of"different treatments for the same disease"in migraine.Methods Retrieve the effective ingredients of Banxia Baizhu Tianma Decoction and Qianghuo Shengshi Decoction through the TCMSP database,and predict potential targets in SwissTargetPrediction,the disease genes of migraine were obtained by TTD,GeneCards,and OMIM database.The data were analyzed using the Cytoscape 3.9.1 software,and the STRING database was used to construct the PPI network.DAVID database was used for pathway enrichment analysis.Finally,the key targets and key components with large degree values in the component-target network were selected,and molecular docking was performed using AutoDock software.Results There were 320 common targets in Banxia Baizhu Tianma Decoction and Qianghuo Shengshi Decoction,319 targets specific to Banxia Baizhu Tianma Decoction,and 66 targets specific to Qianghuo Shengshi Decoction.They may act on migraine through IL6,AKT1,TNF,VEGFA and other common key targets,as well as HIF-1 and IL-17 signaling pathway.Among them,Banxia Baizhu Tianma Decoction exerted its specific effects through 5-hydroxytryptaminergic synapses enriched by proteins such as GABRB3,CHRM2,and GABRB2,the neuroactive ligand-receptor interaction pathway,and the MAPK signaling pathway.Qianghuo Shengshi Decoction could have unique therapeutic effects on migraine through the PI3K-Akt signaling pathway where IL10 and CAMK2B were located,and through the regulation of cell survival and other pathways.The results of molecular docking show that the key components bind to the key targets in a stable structure.Conclusion Banxia Baizhu Tianma Decoction is used to treat the migraine of endogenous wind and phlegm,while Qianghuo Shengshi Decoction is used to treat the migraine of exogenous wind and dampness.Network pharmacological analysis finds that both have common targets and pathways,as well as their own unique targets and pathways.By analyzing the differences in targets and pathways,the biological basis of the different types of migraine with different treatments for the same disease can be initially elucidated.
Banxia Baizhu Tianma DecoctionQianghuo Shengshi Decoctionmigrainedifferent treatments for the same diseasenetwork pharmacology
国家科技期刊平台
NSTL
万方数据
维普
