Exploration on the Mechanism of Jianwei Qingchang Mixture in Treating Acute Pancreatitis Based on Network Pharmacology
Objective To investigate the mechanism of Jianwei Qingchang Mixture in the treatment of acute pancreatitis(AP)based on network pharmacology.Methods Based on TCMSP and HERB data platforms,the main active components of Jianwei Qingchang Mixture were screened.AP related disease targets were retrieved from GeneCards,OMIM,and DrugBank databases,and common targets for the active components of Jianwei Qingchang Mixture and acute pancreatitis were screened out;protein interaction networks for drug-disease common targets was constructed through STRING Database;DAVID platform was used for GO function and KEGG pathway enrichment analysis;Cytoscape 3.9.1 software was used to construct a drug-active component-target-pathway network;network topology was used to screen key active components and core targets of Jianwei Qingchang Mixture in the treatment of AP.Results Totally 37 active components of Jianwei Qingchang Mixture were obtained,including emodin,quercetin,chuanchen retin,etc.,123 targets of Jianwei Qingchang Mixture in the treatment of AP were obtained,and the core targets were PTGS2,HSP90AA1,PTGS1,etc.,and the enrichment results of KEGG signaling pathway showed that Jianwei Qingchang Mixture mainly acted on IL-17 signaling pathway,TNF signaling pathway,PI3K-Akt and other signaling pathways.Conclusion Jianwei Qingchang Mixture may act on PTGS2,HSP90AA1,PTGS1 and other targets through active components such as quercetin,β-sitosterol,naringenin and chuanchen reticetin,and then regulate IL-17 signaling pathway,TNF signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway to inhibit inflammatory response,antioxidation,regulate autophagy,affect apoptosis,and exert therapeutic effects on AP with multiple components,targets and pathways.
国家科技期刊平台
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