Study on the TCM Syndrome Types and Medication Law of Arsenic-containing TCM Compounds for the Treatment of Myelodysplastic Syndrome
Objective To explore the TCM symptom types and medication law for the treatment of myelodysplastic syndrome based on arsenic-containing TCM compounds through data mining.Methods The information data of patients with myelodysplastic syndrome who visited the Hematology Clinic of Xiyuan Hospital of China Academy of Chinese Medical Sciences from April 2,2014 to October 31,2021 were screened by the HIS system,and a standardized database was established to standardize drug names and diagnoses.The Ancient and Modern Medical Case Cloud Platform 2.3.5 was used to perform statistics,association rules,clustering analysis and complex network analysis of basic patient information,TCM syndrome types,and TCM prescriptions.The data were visualized in combination with Cytoscape 3.8.0.Results A total of 457 patients were enrolled,including 413 cases of spleen and kidney deficiency and toxin stasis stagnation,and 44 cases of qi-yin deficiency and toxin stasis stagnation.A total of 819 TCM prescriptions were included,involving 346 kinds of Chinese materia medica,and the drug application frequency was relatively high,such as Realgar,Indigo Naturalis,Poria,fried Atractyodis Macrocephalae Rhizoma and Rehmannize Radix et Praeparata,etc.The main tastes were sweet,pungent and bitter,and the main properties were mild,warm and cold,and the main meridians were kidney,liver and spleen meridians.In the analysis of association rules,51 medicinal pairs were obtained from the Chinese materia medica and analysis,among which the highest degree of improvement was Cuscutae Semen-Psoraleae Fructus.The analysis of syndrome types and Chinese materia medica obtained 9 sets of results,and the highest improvement was qi-yin deficiency syndrome →Poria.Clustering analysis yielded 6 groups of prescriptions with different formulas,such as Qinghuang Powder,Sijunzi Decoction,and Liuwei Dihuang Decoction.A total of 22 kinds of Chinese materia medica were involved in the complex network,and the highest node degree was Indigo Naturalis and Realgar.Conclusion The TCM syndrome types of myelodysplastic syndrome is mainly characterized by spleen and kidney deficiency and toxin stasis stagnation.Qinghuang Powder,composed of Realgar and Indigo Naturalis,is clinically combined with TCM decoction mainly to replenish the spleen and benefit the kidney,and uses arsenic-containing TCM compounds form to support healthy qi while clearing heat and detoxification,activating blood circulation and removing stasis.
myelodysplastic syndromearsenic-containing TCM compoundsdata miningTCM syndrome typesmedication law
国家科技期刊平台
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