Exploration on the Mechanism of main drugs of Qingshen Granule in Treating Chronic Kidney Disease Based on Network Pharmacology
Objective To explore the mechanism of main drugs of Qingshen Granule of Rheum officinale,rhizoma coptidis,Hedyotis diffusa,and salvia miltiorrhizae in treating chronic kidney disease(CKD)based on network pharmacology.Methods TCMSP and SwissTargetPrediction databases were used to retrieve the active components and targets of of the four kinds of Chinese materia medica.OMIM,GeneCards and TTD databases were used to obtain disease targets.STRING database was used to screen core targets.GO function and KEGG pathway enrichment analysis was carried out.Cytoscape 3.7.2 software was used to construct PPI network.Results Totally 99 active components,873 action targets were obtained and 102 intersecting targets for the treatment of CKD with active components.The main active components included quercetin,luteolin,danshenol A,etc.The key targets involved VEGFA,EGFR,AKT1,etc.The GO function analysis results showed that targets such as VEGFA,EGFR,and SRC were involved in the treatment of CKD.The KEGG pathway enrichment analysis results showed that the treatment of CKD with Rheum officinale,rhizoma coptidis,Hedyotis diffusa and salvia miltiorrhizae mainly involved signaling pathways such as HIF-1,PI3K-Akt,Rap1,and MAPK.Conclusion Rheum officinale,rhizoma coptidis,Hedyotis diffusa and salvia miltiorrhizae may regulate target such as VEGFA,EGFR and SRC for CKD through signaling pathways such as HIF-1 and PI3K-Akt.
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