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基于数据挖掘探讨喻闽凤治疗儿童抽动障碍用药规律

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目的 利用数据挖掘研究喻闽凤教授治疗儿童抽动障碍的用药规律.方法 收集2018年1月1日-2021年12月31日广州中医药大学第四临床医学院喻闽凤教授门诊治疗儿童抽动障碍病例,利用Excel2016建立数据库,利用古今医案云平台2.3.5进行用药频次、性味归经分析,关联规则分析、聚类分析及复杂网络分析.结果 共纳入首诊处方142首,涉及中药139味,高频药物为天麻、白芍、大枣、法半夏、炙甘草、玄参、太子参、茯苓、杜仲、牛膝,药性以温、平为主,药味多为甘、苦、辛味,主要归肝经、脾经,其后为肺经、胃经、肾经、心经等.关联分析得到37个常用药对,聚类分析得到3类药物组合,复杂网络分析得到的核心中药组成以牛膝木瓜汤和正阳汤为基础加减.结论 喻闽凤教授治疗儿童抽动障碍以脾虚肝旺为关键病机,从肝论治,以疏肝理气、清肝平肺、补肝息风为法,综合运用脏腑理论及五运六气理论指导儿童抽动障碍的治疗.
Discussion on the Medication Law of Yu Minfeng in the Treatment of Tic Disorders in Children Based on Data Mining
Objective To explore the medication law of Professor Yu Minfeng in the treatment of children with tic disorder with data mining.Methods The cases of children with tic disorder in the Fourth Clinical Medicine School of Guangzhou University of Chinese Medicine from 1 January 2018 to 31 December 2021 were collected.Excel 2016 was used to establish the patient database.The medicine frequency statistics,medicine properties,tastes and meridians,association analysis,clustering analysis and complex network analysis were performed by using the ancient and modern medical records cloud platform 2.3.5.Results A total of 142 first-diagnosed prescriptions were included,involving 139 kinds of Chinese materia medica.The high-frequency drugs were Atractylodis Macrocephalae Rhizoma,Paeoniae Radix alba,Jujubae Fructus,Pinelliae Rhizoma Praeparatum,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,Scrophulariae Radix,Pseudostellariae Radix,Poria,Eucommiae Cortex,and Cyathulae Radix.The properties were mainly warm and mild;the tastes were mainly sweet,bitter and pungent;the meridians were mainly liver and spleen meridians,which followed lung meridian,stomach meridian,kidney meridian and heart meridian.Association analysis obtained 37 commonly used drug pairs,clustering analysis obtained 3 types of drug combinations,and complex network analysis indicated that the core TCM prescriptions were added and subtracted based on Niuxi Mugua Decoction and Zhengyang Decoction.Conclusion Professor Yu Minfeng grasps the key pathogenic mechanism of spleen deficiency and liver prosperity in treating children's tic disorders.The treatment should be based on the liver,using the methods of soothing the liver and regulating qi,clearing the liver and calming the lung,and supplementing the liver and calming the wind.The comprehensive application of the theory of organs and the theory of five elements and six qi should guide the treatment of children with tic disorders.

children with tic disordersdata miningYu Minfengmedication law

邓琳蓉、喻闽凤、傅瑶、徐东亚

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广州中医药大学第四临床医学院,广东 深圳 518000

深圳市中医院,广东 深圳 518033

儿童抽动障碍 数据挖掘 喻闽凤 用药规律

广东省名中医传承工作室建设项目(2020年)广东省深圳市医疗卫生三名工程项目深圳市中医院"3030计划"中医临床研究项目

SZSM201812064G3030202122

2024

中国中医药图书情报杂志
中国中医科学院中医药信息研究所

中国中医药图书情报杂志

影响因子:0.556
ISSN:2095-5707
年,卷(期):2024.48(2)
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