Study on the"Different Diseases with the Same Treatment"of Kawasaki Disease and Henoch-Schonlein Purpura with Xijiao Dihuang Decoction Based on Network Pharmacology
Objective To analyze the mechanism of"different diseases with the same treatment"of Kawasaki disease and Henoch-Schonlein purpura with Xijiao Dihuang Decoction using network pharmacology;To provide reference for related research.Methods The active components and action targets of Xijiao Dihuang Decoction were retrieved from TCMSP database.The target genes of Kawasaki disease and Henoch-Schonlein purpura were retrieved from GeneCards,OMIM and DrugBank databases,and the PPI network was constructed by STRING platform.The Metascape platform was used to analyze the biological processes and pathways involved in the targets,and then the network of"Xijiao Dihuang Decoction-Kawasaki disease and Henoch-Schonlein purpura target-pathway"was constructed.Finally,molecular docking was performed to verify the results.Results The core components of Xijiao Dihuang Decoction in the treatment of Kawasaki disease and Henoch-Schonlein purpura were quercetin,kakaferol,baicalein,etc.,and the core targets were IL6,AKT1,etc.The biological pathways of Xijiao Dihuang Decoction in the treatment of Kawasaki disease and Henoch-Schonlein purpura mainly acted on vascular disease pathway and inflammatory factor pathway,and its function was mainly to regulate the life activities of cytokines and signal receptors.GO enrichment analysis showed that the intersection targets were enriched in cytokine interaction and signal interaction.Conclusion Xijiao Dihuang Decoction can reach the goal of"different diseases with the same treatment"of Kawasaki disease and Henoch-Schonlein purpura by protecting vascular endothelium,anti-inflammation,and regulating immunity.The mechanism is that quercetin and other substances inhibit the production of IL6 and AKT1,prevent the activation of TNF signaling pathway,and protect the fluid shear stress spectrum.
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