Effects of Three TCM Injections Combining Western Medicine with Antiviral Drugs on Inflammatory Factors in Patients with Viral Pneumonia:a Network Meta-analysis
Objective To compare the efficacy of Xuebijing Injection,Reduning Injection and Tanreqing Injection on the levels of inflammatory factors in the treatment of patients with viral pneumonia by means of network Meta-analysis.Methods Randomized controlled trials(RCTs)about three Injection respectively combined with Western medicine for the treatment of viral pneumonia were retrieved from CNKI,Wanfang Data,VIP,CBN,PubMed,Embase,and Cochrane Library from the establishment of the databases to April 15,2022.The included literature was evaluated according to the Cochrane Manual of 5.1.0 Bias Risk Assessment,and the Stata 15.1 software was used for Meta-analysis.Results The study included 26 RCTs with a total of 2 315 patients.The results of network Meta-analysis showed that in terms of total effective rate,there was a statistically significant difference between Western medicine antiviral therapy + Reduning Injection and Western medicine antiviral therapy + Xuebijing Injection[OR=5.69,95%CI(3.37,9.61),P<0.05]and using Western medicine antiviral therapy alone[OR=5.51,95%CI(2.92,8.94),P<0.05],while the other differences were not statistically significant.In terms of reducing C-reactive protein,Western medicine antiviral therapy + Tanreqing Injection had the best effect.In terms of reducing interleukin-6,there were statistically significant differences in treatment between Western medicine antiviral therapy + Tanreqing Injection and Western medicine antiviral therapy + Reduning Injection[OR=-2.51,95%CI(-4.29,-0.73),P<0.05],Western medicine antiviral therapy + Tanreqing Injection and Western medicine antiviral therapy[OR=-1.90,95%CI(-2.57,-1.22),P<0.05],and there was no statistically significant difference between Western medicine antiviral treatment + Reduning Injection and Western medicine antiviral treatment alone.In terms of reducing tumor necrosis factor-α,there was no statistically significant difference in the use of Western medicine antiviral therapy + Reduning Injection compared to Western medicine antiviral therapy.Compared with Western medicine antiviral therapy[OR=-1.98,95%CI(-2.62,-1.34),P<0.05],there were statistically significant differences in treatment of Western medicine antiviral therapy + Tanreqing Injection and Western medicine antiviral therapy + Reduning Injection[OR=-2.62,95%CI(-3.63,-1.61),P<0.05].In terms of the incidence of adverse reactions,there was statistically significant difference in the treatment of Western medicine antiviral therapy + Reduning Injection compared to Western medicine antiviral therapy[OR=0.38,95%CI(0.18,0.79),P<0.05],while the rest had no statistically significant difference.Conclusion TCM injections combined with Western medicine antiviral treatment of viral pneumonia is more effective than Western medicine antiviral treatment alone,with good safety,which can effectively reduce the level of inflammatory factors,and Tanreqing Injection has the best efficacy.
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