艾灸治疗腹泻型肠易激综合征研究进展
Research Progress in Moxibustion Treatment for Diarrhea-predominant Irritable Bowel Syndrome
杨灿灿 1孙建华1
作者信息
- 1. 南京中医药大学附属医院,江苏 南京 210004
- 折叠
摘要
肠易激综合征(IBS)在各年龄段均有发作,且以腹泻型肠易激综合征(IBS-D)最为多见.目前对IBS-D的具体发病机制尚未阐明,主要将其归因于神经-内分泌-免疫功能紊乱、内脏超敏反应、胃肠动力异常及精神心理因素等.中医学将IBS-D归属"泄泻""大肠泄"范畴,其病程较长,证型复杂多变,治疗难度大.本文对艾灸治疗IBS-D的研究进行综述,发现艾灸可通过刺激相应腧穴以调节核因子-κB信号通路、影响5-羟色胺受体、调节血管活性肠肽和P物质等神经递质、调控c-Kit/SCF信号轴及调整肠道菌群来缓解IBS-D的症状.
Abstract
Irritable bowel syndrome(IBS)is a common functional gastrointestinal disorder that can occur in all age groups,with diarrhea-predominant IBS(IBS-D)being the most common type.Currently,the specific pathogenesis of IBS-D has not been determined,and it is mainly attributed to neuroendocrine-immune dysfunction,visceral hyperalgesia,abnormal gastrointestinal motility,intestinal microbiota imbalance,abnormal bile acid absorption,and psychological factors.TCM categorizes IBS-D into the categories of"diarrhea"and"large intestine diarrhea",with a long course,complex and variable syndrome types,and high difficulty in treatment.This article reviewed the research on moxibustion treatment of IBS-D and found that moxibustion could regulate NF-κB signaling pathway by stimulating corresponding acupoints,affecting 5-HT receptors,regulating neurotransmitters,such as VIP and SP,regulating c-Kit/SCF signaling axis and gut microbiota to alleviate symptoms of IBS-D.
关键词
腹泻型肠易激综合征/艾灸/经络腧穴/炎症因子/肠道菌群/综述Key words
irritable bowel syndrome/moxibustion/meridian acupoints/inflammatory factors/intestinal flora/review引用本文复制引用
基金项目
国家自然科学基金面上项目(82274630)
国家自然科学基金面上项目(82174489)
国家中医药管理局中医药古籍文献和特色技术传承项目(GZY-KJS-2020-077)
江苏省中医药管理局重点项目(ZD202224)
出版年
2024
国家科技期刊平台
NSTL
万方数据