首页|基于数据挖掘探讨《医方考》含半夏处方用药规律

基于数据挖掘探讨《医方考》含半夏处方用药规律

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的 探讨《医方考》含半夏处方的用药规律.方法 收集《医方考》中含半夏处方,运用中医传承计算平台3.0、SPSS Statistics 27.0及SPSS Modeler 18.0软件对处方进行量效分析、配伍统计、频次统计、关联分析及聚类分析.结果 共纳入处方63首,半夏用量均值为36.5 g,多以炮制半夏入方以减毒;补虚药、理气药、解表药、清热药、利水渗湿药、化痰止咳平喘药与半夏配伍频次较高,高频药物为甘草(45次)、陈皮(33次)、茯苓(28次)、人参(25次)等,关联规则及核心配伍组合发现,半夏-陈皮-茯苓、半夏-人参-甘草关联度较强;K-means聚类分析得到3个聚类:①半夏、甘草、人参、干姜、地黄;②半夏、甘草、陈皮、茯苓、白术;③半夏、甘草、生姜、人参、黄芩.结论 在《医方考》收录处方中,半夏多与补虚药、理气药、解表药、清热药、利水渗湿药、化痰止咳平喘药相配伍.
Discussion on the Medication Law of Prescriptions with Pinelliae Rhizoma in Yi Fang Kao Based on Data Mining
Objective To explore the medication law of the prescriptions containing Pinelliae Rhizoma in Yi Fang Kao.Methods The prescriptions containing Pinelliae Rhizoma were collected from the Yi Fang Kao.Traditional Chinese Medicine Inheritance Calculation Platform 3.0,SPSS Statistics 27.0,and SPSS Modeler 18.0 software were used to conduct dose-response analysis,compatibility statistics,frequency statistics,correlation analysis,and clustering analysis on prescriptions.Results A total of 63 prescriptions were included,among which the average dosage of Pinelliae Rhizoma was 36.5 g.Most of them used prepared Pinelliae Rhizoma to reduce the toxicity;medicines for tonic,qi-regulating,exterior-relieving,heat-clearing,diuretic and dampness-reducing,phlegm-resolving and cough-relieving medicines showed high compatibility frequency with Pinelliae Rhizoma.The high-frequency drugs were Glycyrrhizae Radix et Rhizoma(45 times),Citri Reticulatae Pericarpium(33 times),Poria(28 times),Ginseng Radix et Rhizoma(25 times),etc.The association rules and core compatibility combinations found that the correlation of Pinelliae Rhizoma-Citri Reticulatae Pericarpium-Poria and Pinelliae Rhizoma-Ginseng Radix et Rhizoma-Glycyrrhizae Radix et Rhizoma were strong;K-means cluster analysis resulted in 3 clusters:①Pinelliae Rhizoma,Glycyrrhizae Radix et Rhizoma,Ginseng Radix et Rhizoma,Zingiberis Rhizoma and Rehmannine Radix;② Pinelliae Rhizoma,Glycyrrhizae Radix et Rhizoma,Citri Reticulatae Pericarpium,Poria and Atractylodis Macrocephalae Rhizoma;③Pinelliae Rhizoma,Glycyrrhizae Radix et Rhizoma,Zingiberis Rhizoma Recens,Ginseng Radix et Rhizoma andScutellariae Radix.Conclusion Among the prescriptions in Yi Fang Kao,Pinelliae Rhizoma is mostly compatible with tonic drugs,qi-regulating drugs,exterior-removing drugs,heat-clearing drugs,diuretic and dampness-removing drugs,phlegm-reducing,cough-relieving and asthma-relieving drugs,etc.

Yi Fang KaoPinelliae Rhizomaspleen and stomachdosage-effect relationshipdata mining

刘容辰、魏文一、邢亚丹、李琳荣

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山西中医药大学基础医学院,山西 晋中 030619

医方考 半夏 脾胃 量效关系 数据挖掘

省级名中医传承工作室建设项目山西中医药大学研究生创新创业项目(2021)

SXSMZYGZS1722021CX005

2024

10.3969/j.issn.2095-5707.202302097

中国中医药图书情报杂志
中国中医科学院中医药信息研究所

中国中医药图书情报杂志

影响因子：0.556
ISSN：2095-5707
年,卷(期)：2024.48(3)
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