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基于数据挖掘探讨中医药治疗胃癌术后用药规律

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目的 基于数据挖掘技术分析中医药治疗胃癌术后的药物配伍规律及核心处方,以期为临床用药提供参考.方法 计算机检索中国知识资源总库(CNKI)、万方数据知识服务平台(万方数据)、中文科技期刊数据库(维普网)建库至2022年12月1日中医药治疗胃癌术后的相关文献,经数据筛选及规范化处理后,运用古今医案云平台2.3.5,进行中药频次统计、属性统计、关联规则分析、聚类分析及复杂网络分析,探析中医药治疗胃癌术后的用药频次、性味归经、核心处方等用药规律.结果 共纳入处方173首,涉及药物277味,频次最高的药物为白术(125次).药性以平、温为主,药味以甘、苦为主,主归脾经、肺经、胃经.关联分析显示,白术-茯苓、白术-黄芪、白术-甘草等关联度最高.聚类分析可知治疗胃癌术后中药可分为4组.复杂网络分析发现其核心处方为六君子汤加减.结论 中医药治疗胃癌术后以扶正补虚为主,重用益气健脾和胃之品,兼顾燥湿化痰、消食除积、祛瘀抗癌为用药特点,标本同治,攻补兼施.
Discussion on the Medication Law of TCM for the Treatment of Postoperative Gastric Cancer Based on Data Mining
Objective To analyse the drug compatibility rules and core prescriptions of TCM in the treatment of postoperative gastric cancer based on data mining technology;To provide reference for clinical medication.Methods The literature related to TCM for the treatment of postoperative gastric cancer was retrieved from CNKI,Wanfang Data and VIP from the establishment of the databases to December 1,2022.After data screening and normalization,the Ancient and Modern Medical Records Cloud Platform 2.3.5 was used to conduct frequency statistics,attribute statistics,association rule,clustering analysis and complex network analysis of Chinese materia medica to explore the medication law of frequency,four properties,five tastes and meridian,and core prescriptions of TCM in the treatment of postoperative gastric cancer.Results A total of 173 prescriptions were included,involving 277 kinds of Chinese materia medica.The most frequently used drug was Atractylodis Macrocephalae Rhizoma(125 times).The medicinal properties were mainly mild and warm,and the tastes were mainly sweet and bitter,mainly returning to the spleen,lung and stomach meridians.Correlation analysis showed that Atractylodis Macrocephalae Rhizoma-Poria,Atractylodis Macrocephalae Rhizoma-Astragali Radix and Atractylodis Macrocephalae Rhizoma-Glycyrrhizae Radix et Rhizoma had the highest correlation.Clustering analysis revealed that the herbal medicines for the treatment of postoperative gastric cancer could be divided into four groups.Complex network analysis revealed that their core prescription was modified Liujunzi Decoction.Conclusion TCM treatment for postoperative gastric cancer mainly uses the method to support healthy qi and tonify deficiency,tonify qi and strengthen spleen and stomach,taking into account drying dampness and reducing phlegm,digestion and reducing accumulation,removing blood stasis and anticancer,treating the root and symptoms at the same time,with attacking and tonifying.

Ancient and Modern Medical Records Cloud Platformpostoperative gastric cancerTCMmedication law

张成成、陈民、梁寒星、寇玉、徐海荣

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扬州大学医学院,江苏省中西医结合老年病防治重点实验室,江苏 扬州 225000

古今医案云平台 胃癌术后 中医药 用药规律

江苏省自然科学基金

BK20180928

2024

中国中医药图书情报杂志
中国中医科学院中医药信息研究所

中国中医药图书情报杂志

影响因子:0.556
ISSN:2095-5707
年,卷(期):2024.48(3)
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