Analysis on the Mechanism of Chaihu Jia Longgu Muli Decoction Against Depressive Disorder Based on the Theory of"Five-in-one"
"Five-in-one"is based on the idea of studying classical prescriptions from five aspects:prescription property,prescription location,prescription efficacy,prescription syndrome and modern pharmacology.Through all-round discussion and multi-dimensional analysis,the mechanism of Chaihu Jia Longgu Muli Decoction in the treatment of depressive disorder was analyzed.Its properties are pungent,bitter,sweet and cold.The property of the lung is pungent,the property of heart is bitter,and the property of spleen is sweet.They work together to play the role of antidepressant.The location is Shaoyang.The efficacy is to reconcile Shaoyang,soothe the liver and expel heat,and calm the nerves.The aim is to keep the cardinal unobstructed,scatter ministerial fire,maintain and stimulate the vitality of mental activity.The prescription syndrome is various diseases caused by Shaoyang qi stagnation and heat disturbing mind.Modern pharmacological studies have found that the mechanism of this prescription in the treatment of depressive disorder includes regulating the level of neurotransmitters,up-regulating the expression of brain-derived neurotrophic factors,protecting hippocampal neurons,and regulating inflammatory factors.This article used the"five-in-one"theory to analyze this prescription,in order to have practical significance for clinical application and further excavation of the prescription.
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