Network Pharmacological Study on Mechanism of Agrimoniae Herba in Treating Chronic Fatigue Syndrome
Objective To explore the potential mechanism of Agrimoniae Herba in the treatment of chronic fatigue syndrome using network pharmacology methods.Methods The chemical components and potential targets of Agrimoniae Herba were obtained through SymMap and HERB databases.Chronic fatigue syndrome disease targets were obtained through the DisGeNET database,and intersection targets were obtained by deduplicating the chemical components corresponding to the targets and disease-related targets.Cytoscape 3.9.1 software was used to draw the chemical components of Agrimoniae Herba-intersection target network.STRING database and Cytoscape 3.9.1 software were used to draw intersection targets protein-protein interaction diagrams.David database was used for GO analysis and KEGG pathway analysis.CB-Dock platform was used for molecular docking of key components and core targets.Results Total 21 components and 360 potential targets of Agrimoniae Herba and 118 targets related to chronic fatigue syndrome were obtained.There were 22 intersection targets of Agrimoniae Herba and chronic fatigue syndrome.GO and KEGG analysis showed that 181 biological processes,9 cell components,10 molecular functions and 58 signaling pathways were involved in the main targets of the chronic fatigue syndrome.Molecular docking results showed that quercetin,osthenodin,luteolin,β-sitosterol may have a certain binding force with IL1B,IL6,TNF,PTGS2 target.Conclusion Agrimoniae Herba for the treatment of chronic fatigue syndrome can act the targets of IL1B,IL6,TNF,etc.,through osthenodin,β-sitosterol,kaempferol,quercetin,rhinoceros,etc.The possible mechanisms include regulating inflammation and immune response,improving intestinal immune network,and acting on diabetes and cancer related pathways.
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