Study on Efficacy Evaluation of Kidney-tonifying TCM Compound Preparations for the Treatment of Postmenopausal Osteoporosis Based on Cumulative Meta-Analysis
Objective To systematically evaluate the effectiveness and safety of kidney-tonifying TCM compound preparations for the treatment of postmenopausal osteoporosis(PMOP).Methods Randomized controlled trial(RCTs)of kidney-tonifying TCM compound preparations taken alone or combined with conventional therapy for the treatment of PMOP were retrieved from CNKI,Wanfang Data,VIP,CBM,PubMed,Cochrane Library and Embase from 1st,Jan.2007 to 31st,July 2022.Cochrane system evaluator manual 5.1.0 was used for literature quality evaluation,and STATA 14.0 was used for cumulative Meta-analysis.Results A total of 17 RCTs were included.A cumulative Meta-analysis was conducted based on the year of publication in the literature,indicating that kidney-tonifying TCM compound preparations were first proven effective in the treatment of PMOP in 2008,with OR=2.59,95%CI(1.28,5.23),P<0.05.A cumulative Meta-analysis was conducted by sorting the sample size,indicating that the OR value of kidney-tonifying TCM compound preparations in the treatment of PMOP was relatively stable,and its accuracy was generally increasing[OR=2.84,95%CI(1.93,4.17),P<0.05],which indicated that the treatment group had a higher effective rate than the control group.According to the cumulative Meta-analysis conducted by the year of publication in the literature,it was suggested that the combination of kidney-tonifying TCM compound preparations and Western medicine was first proven effective in the treatment of PMOP in 2011,with OR=5.63,95%CI(1.55,20.43),P<0.05.The cumulative Meta-analysis conducted in order of sample size showed that the OR value of kidney-tonifying TCM compound preparations combined with Western medicine in the treatment of PMOP was relatively stable,and its accuracy showed an overall increasing trend[OR=3.49,95%CI(2.26,5.38),P<0.05],indicating the treatment group was significantly better than the control group,and the changes over time gradually tended to stabilize.The possibility of publication bias using Egger test was extremely low.Conclusion Kidney-tonifying TCM compound preparations have a definite therapeutic effect on PMOP,and are significantly better than simple Western medicine treatment.It is worth promoting and using in orthopedic clinical practice.
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