Discussion on the Mechanism of Biwen Pills from Zhong Fu Tang Gong Xuan Liang Fang in Preventing COVID-19 Based on Network Pharmacology
Objective To explore the mechanism of Biwen Pills in preventing COVID-19 based on network pharmacology.Methods The chemical components and targets of action of Biwen Pills were retrieved through the TCMSP database;the disease targets were screened by searching the GeneCards,OMIM,PharmGKB,TTD and DrugBank databases.Then STRING was applied to build the network of protein-protein interaction network(PPI).Cytoscape 3.9.0 software was used to build the"drug-target"network diagram and core targets of Biwen Pills in preventing COVID-19 were obtained.The R language and KOBAS database was used to perform GO and KEGG enrichment analysis.Results There were 115 chemical components in Biwen Pills,with a total of 2378 target points.There were 101 overlapping targets between Biwen Pills and COVID-19,with the main core targets being TP53,HSP90AA1,AKT1,and MAPK3;102 signaling pathways were obtained from KEGG analysis,mainly involving IL-17 signaling pathway,TNF signaling pathway,p53 signaling pathway,AGE-RAGE signaling pathway,etc;after GO analysis,a total of 2 359 biological processes,423 cell compositions,and 161 molecular functions were obtained.Conclusion Biwen Pills can regulate apoptosis,promote immunity and anti-virus through TP53,HSP90AA1,AKT1,MAPK3 targets,IL-17,TNF,P53,AGE-RAGE signaling pathways,and exert pharmacological therapeutic effects in preventing COVID-19.
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