基于数据挖掘探讨中药联合化疗治疗胃癌术后用药规律
Exploration on the Medication Law of TCM Combined with Chemotherapy in the Treatment of Postoperative Gastric Cancer Based on Data Mining
朱培 1董皖辉1
作者信息
- 1. 安徽中医药大学附属六安市中医院,安徽 六安 237006
- 折叠
摘要
目的 通过数据挖掘方法探究中药联合化疗治疗胃癌术后组方用药规律.方法 检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)建库至2023年6月9日中药联合化疗治疗胃癌术后相关文献,采用Excel2021录入数据并进行中药频次统计和属性分析,采用IBM SPSS Modeler 18和SPSS Statistics 27软件进行关联规则和聚类分析.结果 纳入处方122首,涉及中药148味,总频次1 469次,使用较多的中药有白术、黄芪、甘草;功效频次排名前5位依次为补虚药、清热药、利水渗湿药、理气药、活血化瘀药;性味以甘温为主,归经以脾经为主.关联规则分析得到支持度最高中药组合为黄芪-白术.系统聚类分析将药物聚为8类.结论 中药联合化疗治疗胃癌术后治法以益气健脾为主.
Abstract
Objective To investigate the medication law of TCM combined with chemotherapy in the treatment of postoperative gastric cancer through data mining methods.Methods The literature related to TCM combined with chemotherapy in the treatment of postoperative gastric cancer was retrieved from CNKI,Wanfang Data and and VIP from the establishment of the databases to June 9,2023.Excel 2021 was used to input data and conduct frequency statistics and attribute analysis of Chinese materia medica.IBM SPSS Modeler 18 and SPSS Statistics 27 software were used for association rules and clustering analysis.Results A total of 122 prescriptions were included,involving 148 kinds of Chinese materia medica,with a total frequency of 1 469 times.The most frequently used Chinese materia medica were Atractylodis Macrocephalae Rhizoma,Astragali Radix and Glycyrrhizae Radix et Rhizoma.The top five efficacy frequency were tonic drugs,heat-clearing drugs,water-clearing and dampness-percolating drugs,qi-regulating drugs,and blood-activating and stasis-dissolving drugs.The property and taste were mainly sweet and warm,and the meridian was mainly spleen meridian.Association rule analysis showed that the highest support Chinese medicine combination was Astragali Radix-Atractylodis Macrocephalae Rhizoma.Systematic clustering analysis clustered the drugs into 8 categories.Conclusion Tonifying qi and strengthening the spleen should be the foundation of TCM combined with chemotherapy for the treatment of postoperative gastric cancer.
关键词
数据挖掘/中医药/胃癌术后/用药规律Key words
data mining/TCM/postoperative gastric cancer/medication law引用本文复制引用
基金项目
安徽中医药大学附属六安市中医院校级科研基金(2021LAYB002)
出版年
2024
国家科技期刊平台
NSTL
万方数据