Exploration on the Mechanism of Yiqi Congming Decoction in Treating Cervical Vertigo Based on Network Pharmacology and Molecular Docking Technique
Objective To explore the mechanism of Yiqi Congming Decoction in treating cervical vertigo(CV)based on network pharmacology and molecular docking technique.Methods TCMSP was used to screen out the active components and related action targets of Yiqi Congming Decoction.CV-related targets were obtained through GeneCards and OMIM databases,and the obtained action targets of Yiqi Congming Decoction were intersected with CV-related disease targets and imported into the STRING database for analysis.In addition,Cytoscape 3.7.2 software was used to construct the protein interaction(PPI)network.R4.2.6 software was used for GO function and KEGG pathway enrichment analysis,and AutoDock 1.5.7 software was used for molecular docking and visualization.Results A total of 232 kinds of active components and 256 targets of Yiqi Congming Decoction were retrieved.The core active components included quercetin,kaempferol,beta-sitosterol,stigmasterol,and formononetin,and 3 230 CV-related targets were identified,among which AKT1,IL6,TP53,CASP3,VEGFA and so on were the core targets.KEGG pathway enrichment analysis showed that AGE-RAGE,IL-17 and TNF signaling pathways were mainly involved in the treatment of CV.The results of molecular docking showed that the core target had strong docking activity with the core active components.Conclusion Yiqi Congming Decoction may act on AKT1,IL6,TP53,CASP3 and VEGFA through active components such as quercetin,kaempferol,beta-sitosterol,stigmasterol,and formononetin,to regulate AGE-RAGE,IL-17 and TNF signaling pathways in treating CV.
万方数据
维普
