Analysis on Medication Law of TCM in the Treatment of Diabetic Encephalopathy Based on R Language Data Mining
Objective To mine the prescription information of diabetic encephalopathy(DE)in modern literature;To provide a new idea for the treatment of DE with Chinese materia medica.Methods Literature about TCM treatment for DE was retrieved from CNKI,Wanfang Data,and VIP from the establishment of the databases to June 18,2023.Raw data were extracted using Tidyverse and Reshape2 packages in R 4.3.0.Excel 2019 was used to conduct statistical analysis on property,taste and meridians of drugs.The itemFrequency function was used to calculate drug frequency.Apriori algorithm was used for association rule analysis.Hierarchical clustering analysis of high-frequency drugs was conducted using R language factoextra package.Correlation analysis and factor analysis of binary variables in Chinese materia medica were conducted using the psych package.Results Totally 57 prescriptions were included,involving 112 kinds of Chinese materia medica,with a total frequency of 420 times.The top 10 kinds of Chinese materia medica were Acori Tatarinowii Rhizoma,Astragali Radix,Poria,Glycyrrhizae Radix et Rhizoma,Ginseng Radix et Rhizoma,Rehmannize Radix et Praeparata,Polygalae Radix,Coptidis Rhizoma,Chuanxiaong Rhizoma and Angelicae Sinensis Radix;the properties and tastes were mainly sweet and warm,bitter and cold,supplemented with pungent and neutral,and the main meridian was spleen meridian;most of the prescriptions had the efficacy of clearing heat,opening orifices,calming the mind,invigorating the spleen and so on.In the correlation analysis,clustering analysis,and factor analysis,it was found that the correlation between Chuanxiaong Rhizoma-Angelicae Sinensis Radix-Carthami Flos-Persicae Semen was the strongest.Conclusion TCM treatment for DE mainly focuses on the spleen,with the main treatment methods being nourishing qi and yin,clearing heat and generating fluids,supplemented by removing blood stasis and unblocking collaterals,clearing phlegm and opening the orifices.
万方数据
维普
