Exploration on the Medication Law of TCM in Treating Knee Osteoarthritis with Cold and Dampness Obstruction Type Based on R Language Data Mining
Objective To explore medication law of TCM in treating knee osteoarthritis(KOA)with cold and dampness obstruction type based on R language;To provide a reference for the treatment of KOA with cold and dampness obstruction type.Methods The research literature about TCM for the treatment of KOA with cold and dampness obstruction type was retrieved from CNKI,VIP,Wanfang Data,and SinoMed.The prescriptions were entered into Excel 2010 to build prescription database.R4.3.1 software was used for frequency statistics,association rule analysis,and clustering analysis.Results Totally 52 prescriptions were included,involving 102 kinds of Chinese materia medica.The top ten high-frequency medicines Cyathulae Radix,Angelicae Pubescentis Radix,Cinnamomi Ramulus,Angelicae Sinensis Radix,Paeoniae Radix alba,Astragali Radix,Gentianae Macrophyllae Radix,Notopterygii Rhizoma et Radix,Aconiti Lateralis Radix Praeparata,Saposheikovize Radix.The main tastes were bitter,pungent and sweet;the main meridians were liver,lung,and spleen meridians.Association rule analysis obtained drug combinations with Astragali Radix,Notopterygii Rhizoma et Radix,Angelicae Pubescentis Radix,Piperis Kadsurae Caulis,Cinnamomi Ramulus,Chuanxiaong Rhizoma,Mori Ramulus as the core;four drug combinations were obtained through hierarchical clustering analysis.Conclusion TCM treatment for KOA with cold and dampness obstruction type mainly takes dehumidification and pain relief,warming meridian and dredging collaterals,and supplements the liver and kidney.The core drug combination can obtain Jubi Decoction and modified Qifu Maxin Guijiang Decoction.
data miningcold and dampness obstruction typeknee osteoarthritismedication law
万方数据
维普
