目的 了解栀子苷国内外研究现状、热点研究方向和发展趋势，为相关临床研究提供参考。方法 检索中国知识资源总库(CNKI)、Web of Science(WOS)核心合集2008年1月1日-2023年3月1日收录的栀子苷相关研究文献，采用NoteExpress3。5。0将数据合并、分析及筛选剔除，采用GraphPad Prism 8。0。2绘制年发文量折线图，采用CiteSpace6。1。R6将发文作者、机构、国家、热点关键词及变化趋势等建立可视化知识图谱，并对其进行分析。结果 纳入3 290篇文献，中文文献年发文量稳定，英文文献年发文量总体呈上升趋势。中文文献以罗光明、萧伟和杜守颖等为主要作者，并各自建立了相对稳定的研究团队;英文文献以Wu Hong、Liu Jianjun、Wang Zhong等研究团队为主。中文主要发文机构以北京中医药大学、中国中医科学院和江苏康缘药业公司等为主，其中，中国中医科学院与各高校和研究所的合作较为密切;英文主要发文机构有Beijing Univ Chinese Med、China Acad Chinese Med Sci和Nanjing Univ Chinese Med等，且合作关系有显著的地域性。发文最多的国家为中国，其次为韩国、美国，各个国家之间合作欠缺，在共现分析中未出现连线。关键词分析发现，栀子苷中文文献主要集中于化学成分、质量标准、含量测定等方面，英文文献主要集中于化学成分、药理药效、作用机制方面的研究。结论 栀子苷的高标准制备、药物不良反应及药物相互作用的体内研究等可能为栀子苷今后研究的主要方向。
Study on Research Status and Trends of Geniposide Based on CiteSpace
Objective To understand the current status,hot research directions and future trends of geniposide at home and abroad;To provide references for relevant clinical research.Methods Research literature about geniposide in the core set databases of CNKI and Web of Science(WOS)were retrieved from January 1,2008 to March 1,2023.NoteExpress 3.5.0 was used to merge,analyze,and filter out data.CiteSpace 6.1.R6 was used to visualize the authors,institutions,countries,and hot keywords and trends for knowledge graph imaging.Results A total of 3 290 articles were included.The annual publication volume of Chinese literature remained stable,while the overall annual publication volume of English literature showed an upward trend.The Chinese publications were led by Luo Guangming,Xiao Wei and Du Shouying who each established a relatively stable research team;the English publications were contributed by the research teams of Wu Hong,Liu Jianjun and Wang Zhong;the main publishing institutions in Chinese were Beijing University of Chinese Medicine,China Academy of Chinese Medical Sciences and Jiangsu Kang Yuan Pharmaceutical Company,among which China Academy of Chinese Medical Sciences cooperated more closely with various universities and research institutes.The main English publishing institutions included Beijing Univ Chinese Med,China Acad Chinese Med Sci,and Nanjing Univ Chinese Med,with significant regional cooperation relationships.The country with the most publications was China,followed by South Korea and the United States.There was a lack of cooperation between these countries,and no connection was found in the co-occurrence analysis.The keyword analysis found that the Chinese publications of gardenia glucoside mainly focused on chemical composition,quality standard,content determination etc.,while the English publications mainly focused on chemical composition,pharmacological efficacy,and mechanism of action.Conclusion The high standard preparation of geniposide,drug toxicity and side effects,and in vivo studies of drug interactions may be the main directions for future research on geniposide.
万方数据
维普
