Meta-analysis on Maxing Shigan Decoction Combined with Antibiotics in the Treatment of Community-acquired Pneumonia
Objective To conduct a Meta-analysis on the efficacy of Maxing Shigan Decoction combined with antibiotics for the treatment of community-acquired pneumonia.Methods Randomized controlled trials(RCTs)of Maxing Shigan Decoction for the treatment of community-acquired pneumonia were retrieved from CNKI,VIP,Wanfang Data,CBM,PubMed,Cochrane Library and Web of Science(WOS)from the establishment of the databases to February 6,2023.RevMan 5.3 and StataMP 14.0 software were used for Meta-analysis.Results A total of 20 RCTs with 1 443 patients were included.Meta-analysis showed that the total clinical effective rate of the experimental group[MD=-1.59,95%CI(-1.93,-1.25),P<0.000 01]was higher than that of the control group.The experimental group shortened the antipyretic time[MD=-1.59,95%CI(-1.93,-1.25),P<0.000 01],improved cough[MD=-2.13,95%CI(-2.69,-1.58),P<0.000 01],improved sputum[MD=-2.1,95%CI(-2.87,-1.34),P<0.000 01],and reduced lung rale duration[MD=-2.06,95%CI(-2.51,-1.61),P<0.000 01],chest X-ray absorption time[MD=-4.73,95%CI(-6.48,-2.97),P<0.000 01]were all better than the control group.After treatment,serum WBC[MD=-1.22,95%CI(-1.85,-0.59),P=0.000 2],CRP levels[MD=-13.75,95%CI(-21.63,-5.87),P=0.000 6]were lower than the control group;among the antibiotics used in subgroup analysis,the combination of moxifloxacin or cefoperazone/sulbactam with Maxing Shigan Decoction could enhance the therapeutic effect(P<0.05);combination therapy for 7 or 10 days could further shorten the duration of fever and cough(P<0.05).The Egger's test suggested that there may be some publication bias in the study.Conclusion Maxing Shigan Decoction combined with antibiotics can improve the efficacy of antibiotics in the treatment of community-acquired pneumonia.Moxifloxacin or cefoperazone sulbactam can be selected as the combined drug,and the combined course of treatment can be selected for 7 or 10 days.Advantages of combined therapy are more obvious with the extension of treatment course.
万方数据
维普
