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针灸治疗溃疡性结肠炎机制研究进展

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溃疡性结肠炎的发生发展与遗传和环境因素、肠道黏膜屏障功能受损、免疫紊乱及肠道菌群失调密切相关,针灸治疗因能改善溃疡性结肠炎肠道炎症而得到重视.本文从免疫细胞、炎症因子、肠道菌群等方面梳理针灸缓解溃疡性结肠炎作用机制研究,认为其与改善T淋巴细胞间的免疫平衡,抑制白细胞介素(IL)-iβ、IL-6和IL-8等促炎因子表达,调节肠道不同种属菌的丰度,调控巨噬细胞极化,以及抗氧化应激等有关.通过归纳针灸治疗溃疡性结肠炎可能的作用机制,为炎症性肠病相关研究提供参考.
Research Progress in the Mechanism of Acupuncture and Moxibustion for the Treatment of Ulcerative Colitis
The development of ulcerative colitis(UC)is closely related to genetic and environmental factors,impaired intestinal mucosal barrier function,intestinal immunological disorders and dysbiosis of intestinal bacterial flora.Acupuncture and moxibustion treatment has been emphasized for improving intestinal inflammation in UC.In this article,the mechanism of acupuncture and moxibustion in alleviating UC was reviewed from the aspects of immune cells,inflammatory factors and intestinal flora,and believed that acupuncture may exert therapeutic effects by improving the immune homeostasis among T-lymphocytes,inhibiting the expression of pro-inflammatory factors including IL-1β,IL-6 and IL-8,regulating the abundance of different species of intestinal flora,modulating macrophage polarization,and inhibiting oxidative stress.The possible mechanism of acupuncture and moxibustion in the treatment of UC was summarized to provide reference for the related research of inflammatory bowel disease.

acupuncture and moxibustionulcerative colitismechanism studyreview

殷萱、徐世芬、郭修田

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上海中医药大学附属市中医医院,上海 200071

针灸 溃疡性结肠炎 机制研究 综述

2025

中国中医药信息杂志
中国中医科学院中医药信息研究所

中国中医药信息杂志

影响因子:0.889
ISSN:1005-5304
年,卷(期):2025.32(1)